Invitrogen

c-MAF Polyclonal Antibody

c-MAF Antibody in Immunocytochemistry (ICC/IF)

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c-MAF Antibody (PA5-23179) in ICC/IF

Immunofluorescent analysis of cMAF (green) in RPMI 8226 and Daudi cells. Cells were immersion fixed in 4% PFA and permeabilized in 0.5% Triton X-100. Cells were stained with cMAF polyclonal antibody (Product # PA5-23179) at a dilution of 1:500 overnight at 4 degrees, washed in PBS followed by incubation with an Alexa 488 donkey anti-rabbit secondary antibody at a dilution of 1:100 for one hour at room temperature. Data courtesy of the Antibody Data Exchange Program.

c-MAF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

c-MAF Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P))

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产品信息

PA5-23179

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-4 µg/mL

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

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免疫细胞化学 (ICC/IF)

1:500

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流式细胞分析 (Flow)

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产品规格

种属反应

Bovine, Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 75-110 of human c-maf

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2540705

靶标信息

c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK.

Oncogene

Na Y,Hall A,Choi K,Hu L,Rose J,Coover RA,Miller A,Hennigan RF,Dombi E,Kim MO,Subramanian S,Ratner N,Wu J

PA5-23179 was used in Immunohistochemistry to suggest that miR-155 plays a functional role in PNF growth and/or SC proliferation, and that targeting neurofibroma miRs is feasible, and might provide novel therapeutic opportunities.

Mon Feb 01 00:00:00 EST 2021

MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK.

Oncogene

Na Y,Hall A,Choi K,Hu L,Rose J,Coover RA,Miller A,Hennigan RF,Dombi E,Kim MO,Subramanian S,Ratner N,Wu J

Mon Feb 01 00:00:00 EST 2021

MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK.

Oncogene

Na Y,Hall A,Choi K,Hu L,Rose J,Coover RA,Miller A,Hennigan RF,Dombi E,Kim MO,Subramanian S,Ratner N,Wu J

Mon Feb 01 00:00:00 EST 2021

Efferocytosis induces macrophage proliferation to help resolve tissue injury.

Cell metabolism

Gerlach BD,Ampomah PB,Yurdagul A,Liu C,Lauring MC,Wang X,Kasikara C,Kong N,Shi J,Tao W,Tabas I

PA5-23179 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that signaling-triggered apoptotic cell-derived nucleotides can amplify this benefit by increasing the number of these macrophages.

Tue Dec 07 00:00:00 EST 2021

生物信息学

蛋白别名: Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; C-Maf; c-Maf long form; c-maf proto-oncogene; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; Transcription factor Maf; Transcription factor Maf-2; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog

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基因别名: 2810401A20Rik; A230108G15Rik; AW047063; AYGRP; C-Maf; CCA4; cMaf; CTRCT21; MAF; Maf2