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mGluR5 (extracellular) Antibody (PA5-111826) in WB
Western Blot analysis of mGluR5 was performed in rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates. Lane 1,2: mGluR5 (extracellular) Antibody (Product # PA5-111826) at a dilution of 1:400. Lane 3,4: mGluR5 (extracellular) Antibody preincubated with the negative control antigen.
产品信息
PA5-111826
产品规格
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acids 367-380 of rat mGluR5 (Extracellular, N-terminus)
偶联物
Unconjugated
形式
Lyophilized
浓度
0.85 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2857235
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: EGFAQENSKY NKTC
Homology: Mouse amino acid residues identical; human - 13/14 amino residues identical.
靶标信息
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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