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Detects a plaque protein (p0071) specific for a subtype of adherens junctions, with a molecular mass of 135 kD and is closely related to neurojungin/delta-catenin and ARVC (all belonging to the p120 armadillo subfamily). p0071 is specifically detected in the plaques of the composite junctions (area compositae) of cardiac intercalated disks, in puncta adhaerentia of single- and multi-layered epithelia and blood vessel endothelial cells.; it is, however, absent from desmosomes. This protein was also described as plakophilin 4.Reactivity on cultured cell lines: MCF-7, A431, CaCo-2, HT-29, PLC, 16HBE14o, HaCaT, SV80, U333 CG, 3T3, RVF-SMC, MH1C1Positive control: MCF-7 cells.
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Armadillo-related protein; catenin 4; p0071; Plakophilin-4
基因别名: 5031422I09Rik; 9430019K17Rik; Armrp; p0071; PKP4
UniProt ID: (Human) Q99569, (Mouse) Q68FH0
Entrez Gene ID: (Human) 8502, (Bovine) 281406, (Mouse) 227937