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产品信息
67362-1-IG
产品规格
种属反应
Mouse
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
3C7D3
抗原
Cdkn1a Fusion Protein Ag28394
偶联物
形式
Liquid
浓度
1000 µg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Aliquoting is unnecessary for -20°C storage.
靶标信息
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名:
Activating Fragment 1; CDK-interacting protein 1; CDNK1A; Cip1); Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; Melanoma differentiation-associated protein; OTTHUMP00000016298; p21; p21
基因别名: CAP20; CDKI; Cdkn1; Cdkn1a; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; Waf1
UniProt ID: (Mouse) P39689
Entrez Gene ID: (Mouse) 12575
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle
cell cycle arrest
regulation of mitotic cell cycle
negative regulation of cell proliferation
response to UV
negative regulation of gene expression
negative regulation of cell growth
positive regulation of B cell proliferation
cellular response to extracellular stimulus
regulation of protein import into nucleus, translocation
negative regulation of phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of fibroblast proliferation
regulation of cell cycle
cellular response to ionizing radiation
cellular response to UV-B
mitotic cell cycle arrest
signal transduction by p53 class mediator
cellular senescence
negative regulation of G1/S transition of mitotic cell cycle
regulation of DNA biosynthetic process
positive regulation of reactive oxygen species metabolic process
