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产品信息
PA5-19970
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to amino acids 16 of human p53R2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155792
产品详细信息
In Western blot applications, this antibody detects a band at ~39kDa. A suggested positive control is A431 cell lysate.
PA5-19970 can be used with blocking peptide PEP-0095.
靶标信息
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and -gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2 short form beta; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; Ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); TP53-inducible ribonucleotide reductase M2 B
基因别名: MTDPS8A; MTDPS8B; P53R2; RRM2B
UniProt ID: (Human) Q7LG56, (Mouse) Q6PEE3
Entrez Gene ID: (Human) 50484, (Mouse) 382985, (Rat) 299976
kidney development
renal system process
mitochondrial DNA replication
DNA repair
response to oxidative stress
deoxyribonucleoside diphosphate metabolic process
deoxyribonucleoside triphosphate metabolic process
deoxyribonucleotide biosynthetic process
response to amine
nucleobase-containing small molecule interconversion
oxidation-reduction process
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
DNA replication
cellular response to DNA damage stimulus
