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The Human Activin A ELISA quantitates Hu Activin A in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu Activin A.
原理方法
The Human Activin A solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
严格验证
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : EDF, FRP, INHBA
基因ID : (Human) 3624
基因符号 : INHBA
蛋白别名 : Activin beta-A chain, Erythroid differentiation protein, EDF, erythroid differentiation factor, follicle-stimulating hormone-releasing protein, FSH-releasing protein, Inhibin beta A chain, inhibin, beta A (activin A, activin AB alpha polypeptide), Inhibin, beta-1
UniProt ID (Human) P08476