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The Human Bone Morphogenic Protein 4 (Hu BMP-4) ELISA quantitates Hu BMP-4 in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu BMP-4.
原理方法
The Human BMP-4 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
严格验证
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : BMP2B, BMP2B1, BMP4, DVR4, MCOPS6, OFC11, ZYME
基因ID : (Human) 652
基因符号 : BMP4
蛋白别名 : BMP-2B, BMP-4, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, bone morphogenetic protein 4 preproprotein
UniProt ID (Human) P12644