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Human Dnmt3b quantitates human Dnmt3b in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Dnmt3b.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : DNMT3B, ICF, ICF1, M.HsaIIIB
基因ID : (Human) 1789
基因符号 : DNMT3B
蛋白别名 : DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, Dnmt3b
UniProt ID (Human) Q9UBC3