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The Human I-TAC/CXCL11 ELISA quantitates Hu I-TAC in human serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu I-TAC.
原理方法
The Human I-TAC solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
严格验证
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
Interferon-inducible T-cell alpha chemoattractant ( I-TAC), belonging to the CXC chemokine family, is expressed in peripheral blood leukocytes, pancreas and liver, thymus, spleen, lung, small intestine, placenta and prostate. Its molecular weight is 8-11 kD. I-TAC is also known as CXCL-11 and IP-9. The cytokine is involved in regulating calcium release and inducing a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. It is upregulated in patients with AIDS, dementia and in patients with multiple sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : b-R1, CXCL11, H174, I-TAC, IP-9, IP9, ITAC, SCYB11, SCYB9B
基因ID : (Human) 6373
基因符号 : CXCL11
蛋白别名 : Beta-R1, C-X-C motif chemokine 11, chemokine (C-X-C motif) ligand 11, H174, I-TAC, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, IP-9, small inducible cytokine B11, small inducible cytokine subfamily B (Cys-X-Cys), member 11, member 9B, Small-inducible cytokine B11
UniProt ID (Human) O14625