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Human PGRN quantitates human PGRN in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human PGRN.
Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CLN11, GEP, GP88, GRN, PCDGF, PEPI, PGRN
基因ID : (Human) 2896
基因符号 : GRN
蛋白别名 : Acrogranin, Epithelin precursor, Glycoprotein of 88 Kda, GP88, Granulin precursor, granulin-epithelin, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin
UniProt ID (Human) P28799