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The Human Secondary Lymphoid-tissue Chemokine (CCL21) (SLC) Uncoated ELISA Kit contains pre-matched antibody pairs, plates, and reagents for performing quantitative enzyme linked immunosorbent assays (ELISA) to detect and quantify protein levels of human SLC. Wash Buffer and Stop Solution are needed to complete the ELISA reaction and are sold separately.
原理方法
ELISAs are designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody is coated to the bottom of the wells of a microplate, which is an overnight process. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. A sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : 6Ckine, CCL21, CKb9, ECL, SCYA21, SLC, TCA4, UNQ784/PRO1600
基因ID : (Human) 6366
基因符号 : CCL21
蛋白别名 : 6Ckine, beta chemokine exodus-2, Beta-chemokine exodus-2, C-C motif chemokine 21, chemokine (C-C motif) ligand 21, Efficient Chemoattractant for Lymphocytes, secondary lymphoid tissue chemokine, Secondary lymphoid-tissue chemokine, SLC, small inducible cytokine subfamily A (Cys-Cys), member 21, Small-inducible cytokine A21
UniProt ID (Human) O00585