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The InstantOne™ ELISA is specifically engineered for accurate measurement of phosphorylated human STAT5A/B in cell lysates. Detection of mouse and rat STAT5A/B is expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : MGF, STAT5, STAT5A, STAT5B
基因ID : (Human) 6776, (Human) 6777
基因符号 : STAT5A, STAT5B
蛋白别名 : Signal transducer and activator of transcription 5A, Signal transducer and activator of transcription 5B, transcription factor STAT5B
UniProt ID (Human) P42229, (Human) P51692