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Mouse CD80 quantitates mouse CD80 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse CD80.
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : B7, B71, Cd28l, Cd80, Ly-53, Ly53, MIC17, TSA1
基因ID : (Mouse) 12519
基因符号 : Cd80
蛋白别名 : Activation B7-1 antigen, B7, B7 protein, CD80, T-lymphocyte activation antigen CD80
UniProt ID (Mouse) Q00609