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产品规格
检测灵敏度
5.0 pg/mL
测定范围
15.6-1,000 pg/mL
检测样本类型/体积
{Supernatant=50 µL, Serum=50 µL, Plasma=50 µL}
手工操作时间
1 hr 20 min
总时间
3 hr 10 min
均相（无需洗涤）
No
批间差异
5.1%
批内差异
4.4%
检测仪器
Colorimetric Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Standard
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
2-8°C
蛋白名称
IL-10
均相（无需洗涤）
Mouse
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
Biotin
关于本试剂盒
The mouse IL-10 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of mouse IL-10.
Interleukin-10 is a pleiotropic cytokine playing an important role as a regulator of lymphoid and myeloid cell function. It can block cytokine synthesis and several accessory cell functions of macrophages, T-cells, and NK cells. In addition, IL-10 participates in the regulation of proliferation and differentiation of B-cells, mast cells, and thymocytes. Murine IL-10 exhibits strong DNA and amino acid sequence homology to human IL-10 and an open reading frame in the Epstein-Barr virus genome, BCRF1, which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction.
靶标信息
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : CSIF, Il-10, Il10
基因ID : (Mouse) 16153
基因符号 : Il10
蛋白别名 : CSIF, Cytokine synthesis inhibitory factor, IL-10, Interleukin-10
UniProt ID (Mouse) P18893
