Cryo electron microscopy (cryo-EM) using single particle analysis has emerged as a mainstream structural biology technique for the 3D characterization of macromolecules, proteins, and protein complexes at atomic resolution. Decades of dedicated work have refined the hardware, automation, and software needed to bring modern, accessible, and reliable single particle analysis to the structural biology community. Advances in resolution, automation, and artificial intelligence are helping scientists gain greater insights into multiple diseases and their underlying mechanisms.
Explore high impact publications and educational resources covering these topics to learn how this growing technique is providing valuable insights into protein structure and function:
- Membrane proteins
- Cell signaling
- Neuroscience
- Virology
- Cancer
- Agriculture
