混合模式 HPLC 色谱柱 | Thermo Fisher Scientific

Overview

在单次分析中同时分离极性、非极性和可电离化合物

您是否想在单次运行中同时分离离子和疏水性分析物？Thermo Scientific™混合型色谱柱显示出了多种功能，并消除了更换色谱柱、使用离子对或使用多种色谱填料的需要。这些色谱柱固定相将反相和离子交换或HILIC功能性进行结合。

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混合型LC色谱柱

色谱柱	推荐使用
Acclaim™ Trinity P1 LC 色谱柱	同时高效分离药物原料药及其反离子。功能性：SCX、WAX和RP混合型。
Acclaim™ Trinity P2 LC 色谱柱	分离药物反离子，包括单价和二价阳离子或阴离子。功能性：SAX、WCX和HILIC混合型。
Acclaim™混合型WCX-1 LC色谱柱	采用强力可调节选择性分离阳离子型分子。功能性：反相和WCX混合型。
Acclaim™ 混合型WAX-1 LC 色谱柱	当您需要强力选择性用于阴离子型分子分离时，请使用本色谱柱。功能性：反相和WAX混合型。
Acclaim™ 混合型HILIC-1 LC 色谱柱	此种色谱柱可获得反相色谱和亲水相互作用液相色谱（HILIC）的所有优势。功能性：反相和HILIC混合型。
OmniPac™ PAX-100 HPLC 色谱柱	使用溶剂相容阴离子交换色谱柱优化疏水性和卤代物阴离子分离度。功能性：反相和阴离子交换混合型。
OmniPac™ PAX-500 HPLC 色谱柱	在您需要在单次运行中分离阴离子和中性品种时，使用本溶剂相容色谱柱。功能性：反相和阴离子交换混合型。
OmniPac™ PCX-100 HPLC 色谱柱	使用本溶剂相容阳离子交换色谱柱分离疏水阳离子。功能性：反相和阳离子交换混合型。
OmniPac™ PCX-500 HPLC 色谱柱	在单次运行中分离阳离子和中性品种时使用本溶剂相溶混合型色谱柱。功能性：反相和阳离子交换混合型。
GlycanPac™ AXH-1 Glycan Analysis Column	在生物学分子中，对存在不带电荷和带电荷多糖进行定性、定量和结构特征描述。功能性：阴离子交换和反相混合型。
GlycanPac™ AXR-1 LC 色谱柱	使用本HPLC/UHPLC色谱柱获得标记和天然多糖的超高分辨率和选择性。其可以与MS和荧光检测相容。使用电荷、同分异构结构和尺寸组合，此超高性能的硅胶基质色谱柱获得了混合型分离度。功能性：阴离子交换和反相混合型。

Acclaim Trinity P1 HPLC Columns Cation-exchange, anion-exchange, and reversed phase selectivity	Acclaim Trinity P2 HPLC Columns Cation-exchange, anion-exchange, and HILIC selectivity	Acclaim Trinity Q1 HPLC Columns Cation-exchange, anion-exchange, and reversed phase selectivity

Simultaneous separation of polar analytes and their counter ions with high efficiency Suitable for applications including: APIs and counterions Hydrophilic, monovalent ions Small pharmaceuticals	Separation of multivalent cations or anions and pharmaceuticals Suitable for applications including: Multivalent ions and APIs Hydrophilic ions Zwitterions Neutral sugars	Excellent separation of pharmaceuticals and their counter ions Suitable for applications including: Herbicides – diquat and paraquat Pharmaceutical QC
Download specification sheet View column selection	Download specification sheet View column selection	Download specification sheet View column selection

Acclaim Mixed-Mode WAX-1 HPLC Columns Reversed phase and anion-exchange selectivity	Acclaim Mixed-Mode WCX-1 HPLC Columns Reversed phase and cation-exchange selectivity	Acclaim Mixed-Mode HILIC-1 HPLC Columns Reversed phase and HILIC selectivity

Hydrophobic alkyl chain with an anion terminus Powerful selectivity for the separation of difficult mixtures of neutral and anionic analytes Suitable for applications including: Acids/organic acids Hydrophobic cations Hydrophilic anions Peptides Fat-soluble vitamins Pharmaceuticals	Hydrophobic alkyl chain with a carboxyl terminus Powerful selectivity for the separation of difficult mixtures of hydrophobic acids andneutral and cationic analytes Suitable for applications including Hydrophilic cations Hydrophobic anions Bases /Basic pharmaceuticals Aminophenols	Hydrophobic alkyl chain with a diol group at the terminus Provides adjustable selectivity for both polar and nonpolar molecules Suitable for applications including: Highly polar molecules Ethoxylated nonionic surfactants PEGS
Download specification sheet View column selection	Download specification sheet View column selection	Download specification sheet View column selection

Both our Thermo Scientific Acclaim Trinity column line and Thermo Scientific Acclaim Mixed-Mode column line are compatible with the Thermo Scientific Acclaim guard holder and coupler.

Mixed-Mode Liquid Chromatography – An Exciting Development in Separation Science

Discover the latest in mixed-mode liquid chromatography technology, learn about the unique chromatographic properties of mixed-mode columns, and explore analytical challenges that have been addressed by mixed-mode liquid chromatography in this webinar led by Dr. Joachim P. Weiss, Ph.D. and Serdar Bilgesoy.

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Featured resources

Acclaim columns

Explore a wide variety of Acclaim columns to meet your laboratory's application needs with the Acclaim column selection guide.

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Selectivity benefits

Exploring the dual retention mechanism of mixed mode Acclaim WAX-1 columns to tune selectivity in liquid chromatography.

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Environmental

Acclaim Trinity P1 mixed-mode chromatography column coupled with an inert LC system: an innovative approach for underivatized highly polar pesticides separation.

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