If you need a unique antibody or protein conjugate, save time and resources by letting us take care of it for you. Our custom conjugation services team can provide high-quality conjugates for both research and commercial applications. Partner with us so you can focus your energy on innovation while we deliver the conjugates you need.

Get your custom conjugate in three easy steps:

  1. Request a quote to get in touch with our custom labeling services team. Fill out our form with your antibody or protein information as well as your desired label and labeling chemistry. Our team will provide a quote within 3–5 business days along with a shipping label to mail in your antibody.
  2. Send your antibody or protein to our team with the shipping label provided. Our expert team will utilize advanced bioconjugation techniques to efficiently label your antibodies with the desired molecules. Our team will then perform rigorous quality control efforts to help ensure accuracy and reliability of your conjugated antibody or conjugated protein.
  3. Receive your conjugate along with its conjugation data from our expert conjugation team.

Custom conjugation offerings

Our basic conjugation services include standard lysine conjugation, macromolecule crosslinking, and covalent coupling of beads.

 

Standard conjugation

Macromolecule crosslinking

Beads

Labeling ChemistryLysineHeterobifunctional crosslinkCovalent coupling
Label options

Alexa Fluor dyes

Alexa Fluor Plus dyes

pHrodo dyes

LysoLight dyes

DyLights

FITC

Texas Red

ADC toxins

Biotin

R-PE/APC

HRP

ConA

Antibodies/Proteins

Oligos

Standard quality control testing

Concentration

DOL

Free dye check

Concentration

DOL

Amax/A280

Concentration

Bead diameter sizing

Minimum scale range0.2 mg–1 mg0.5–1 mg0.5–1 mg
Estimated yield70%20–40%15–75%

Our advanced conjugation services include small and large site-specific conjugation, bi-specific antibody production, and 1 to 1 antibody conjugation.

 

Site-specific conjugation
(small molecule)

Site-specific conjugation
(large molecule)

Bi-specific antibody production

1 to 1
Antibody conjugation

Labeling ChemistrySiteClick SiteClick SiteClick Lysine or SiteClick
Label options

Alexa Fluor dyes 

Alexa Fluor Plus dyes

pHrodo dyes

LysoLight dyes 

Novafluors 

ADC toxins

Metal-chelating compounds

Biotin

R-PE/APC

HRP

Qdots

 IgG Antibodies

R-PE/APC

Oligonucleotides

Brilliant polymer dyes

 

Standard quality control testing

Concentration

DOL

Free dye check

Concentration

DOL

Free dye check

Concentration

DOL

Free dye check

Concentration

DOL

Free dye check

Minimum scale range0.5 mg1 mg1 mg0.5–1 mg
Estimated yield70%20–50%20–40%10–30%

Our basic conjugation services include standard lysine conjugation, macromolecule crosslinking, and covalent coupling of beads.

 

Standard conjugation

Macromolecule crosslinking

Beads

Labeling ChemistryLysineHeterobifunctional crosslinkCovalent coupling
Label options

Alexa Fluor dyes

Alexa Fluor Plus dyes

pHrodo dyes

LysoLight dyes

DyLights

FITC

Texas Red

ADC toxins

Biotin

R-PE/APC

HRP

ConA

Antibodies/Proteins

Oligos

Standard quality control testing

Concentration

DOL

Free dye check

Concentration

DOL

Amax/A280

Concentration

Bead diameter sizing

Minimum scale range0.2 mg–1 mg0.5–1 mg0.5–1 mg
Estimated yield70%20–40%15–75%

Our advanced conjugation services include small and large site-specific conjugation, bi-specific antibody production, and 1 to 1 antibody conjugation.

 

Site-specific conjugation
(small molecule)

Site-specific conjugation
(large molecule)

Bi-specific antibody production

1 to 1
Antibody conjugation

Labeling ChemistrySiteClick SiteClick SiteClick Lysine or SiteClick
Label options

Alexa Fluor dyes 

Alexa Fluor Plus dyes

pHrodo dyes

LysoLight dyes 

Novafluors 

ADC toxins

Metal-chelating compounds

Biotin

R-PE/APC

HRP

Qdots

 IgG Antibodies

R-PE/APC

Oligonucleotides

Brilliant polymer dyes

 

Standard quality control testing

Concentration

DOL

Free dye check

Concentration

DOL

Free dye check

Concentration

DOL

Free dye check

Concentration

DOL

Free dye check

Minimum scale range0.5 mg1 mg1 mg0.5–1 mg
Estimated yield70%20–50%20–40%10–30%

Optional add-on services

 Purification/buffer exchangeIndividual fractionsDOL optimizationCustom final packaging/formulation
Optional add-on services include

BSA removal

Ascites fluid purification

Unique buffer formulations

Individual fractions with a fraction letter

6 MRs (wide)

3 MRs (narrow)

Lyophilization

Non-standard return buffer

Final packaging over 20 individual aliquots

 Additional QC testing
Optional add-on services include

Bradford

BCA

PAGE

HPLC purity value

HPLC chromatogram

Custom CoA

 Special handling
Optional add-on services include

Low endotoxin

RNAse free

 Purification/buffer exchangeIndividual fractionsDOL optimizationCustom final packaging/formulation
Optional add-on services include

BSA removal

Ascites fluid purification

Unique buffer formulations

Individual fractions with a fraction letter

6 MRs (wide)

3 MRs (narrow)

Lyophilization

Non-standard return buffer

Final packaging over 20 individual aliquots

 Additional QC testing
Optional add-on services include

Bradford

BCA

PAGE

HPLC purity value

HPLC chromatogram

Custom CoA

 Special handling
Optional add-on services include

Low endotoxin

RNAse free

Custom conjugation chemistries explained

basic-antibody-conjugation-110x110


Basic conjugation services

Our basic conjugation services include standard lysine conjugation, macromolecule crosslinking, and conjugation to beads.

  • Standard lysine conjugation utilizes efficient lysine chemistry for reliable labeling with a wide variety of labels. Find the optimal dye for your application and minimize spectral overlap by using our SpectraViewer tool
  • Macromolecule crosslinking utilizes conventional amine and/or cysteine chemistry to conjugate large protein biomolecules
  • Bead conjugation involves covalent attachment of antibodies or proteins to the bead surface, offering versatility across a range of applications
site-specific-antibody-conjugation-110x110


Site-specific conjugation

Our custom bioconjugation capabilities also include Invitrogen SiteClick antibody labeling techniques for highly efficient and site-specific antibody conjugation. SiteClick labeling allows for simple attachment of detection molecules far from the antigen-binding domain, helping provide covalent labeling without altering antibody function. Many detection molecules can be site-selectively attached to antibodies, including:

  • Phycobiliproteins (e.g., R-PE and APC)
  • Alexa Fluor and pHrodo dyes
  • Antibody-drug conjugate toxins
  • Biotin
  • Metal-chelating compounds
  • Qdot probes
bi-specific-antibody-production-110x110


Bi-specific antibody production

We use SiteClick chemistry to create a set of tetravalent bi-specific antibodies. This enables you to choose which pair of antibodies functions best as a bi-specific. Features of our bi-specific custom conjugation offerings include:

  • Crosslink any two IgG antibodies
  • No genetic engineering required
  • Single link between two IgG heavy chains

 

1-to-1-antibody-conjugation-110x100


1 to 1 antibody conjugation

One-to-one antibody conjugation helps ensure precise labeling with high specificity to enhance accuracy and sensitivity in your detection assays. Our one-to-one custom offerings include:

  • RPE for antigen density measurement
  • Oligonucleotide for spatial biology or gene therapy
  • Brilliant polymer dyes for flow cytometry

 

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