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Unlock the secrets to consistent excellence and scale-up success in monoclonal antibody (mAb) manufacturing
The Zurich University of Applied Sciences is a leading Swiss research institution with longstanding life science and pharmaceutical innovation expertise. ZHAW’s Centre for Biochemical Engineering and Cell Cultivation Techniques has a strong reputation for research excellence in cell culture process development, with more than 20 years of bioprocessing experience. This deep subject knowledge has made ZHAW the ideal collaborator for this project.
Gibco products by Thermo Fisher Scientific are designed to help meet the rigorous demands of biomanufacturing. Our innovative solutions, such as the Efficient-Pro Medium and Feed System and the High-Intensity Perfusion (HIP) CHO Medium, are developed to enhance the efficiency and scalability of mAb production processes. The Thermo Scientific DynaDrive Single-Use Bioreactor (S.U.B.) features a revolutionary stir-tank design, offering the advantages of single-use while providing exceptional mixing and higher mass transfer performance that demanding cell lines require. We are committed to providing robust, scalable platforms that streamline development, maximize productivity, and maintain product quality from research to commercial manufacturing.
Fed-Batch Processes
Fed-Batch processing is a widely used bioprocessing method in mAb manufacturing that involves adding nutrients to the bioreactor at set intervals. This controlled approach supports higher cell density and productivity, making it ideal for scaling up production while maintaining consistent product quality.
Our Efficient-Pro Medium and Feed System is specifically engineered for Fed-Batch processes. It enables rapid, seamless scale-up of CHO-K1 cells and ensures robust cell growth and productivity across various stages, from laboratory to large-scale production.
Perfusion
Perfusion is a continuous process where fresh media is steadily supplied and waste is removed, allowing for sustained cell growth at high densities. This process is particularly suited to applications needing high cell viability and rapid production timelines, helping maximize efficiency and resource use.
Our High-Intensity Perfusion (HIP) CHO Medium is designed for perfusion processes, supporting high-density cultures with sustained productivity. It offers a scalable, efficient solution for mAb manufacturing, helping you accelerate timelines while ensuring consistent product quality.
Efficient-ProMedium and Feed 1 enable rapid and seamless upstream process development andscale-up for CHO-K1 cells
In collaboration with ZHAW, our study evaluated the performance of Efficient-Pro Medium and Feed 1 in scaling up CHO-K1 cell cultures using a fed-batch process.
One of the primary challenges addressed was to rapidly identify an optimal medium and feed to help maximize productivity and ensure seamless scaling.
The findings demonstrate the system's robust capability to sustain strong cell growth and high productivity, facilitating a smooth transition from laboratory to production scale. Download the whitepaper to learn how this innovative solution can help optimize your mAb production processes.
Maximizing scale-up efficiency of a mAb upstream process with the Efficient-Pro Medium and Feed system
In a collaborative study using a fed-batch process with CHO-K1 cells, the performance of Efficient-Pro Medium and feed 1 was evaluated on three different scales.
Here, we address the challenges of rapidly identifying an optimal medium and feed, and developing a process for a cell line that maximizes productivity and enables seamless scaling.
This study demonstrates the system's capability to maintain strong cell growth and high productivity, enabling a seamless transition from lab to production scale.
High-Intensity Perfusion (HIP) CHO Medium drives scalable mAb production
In collaboration with ZHAW, our study evaluated the performance of HIP CHO Medium in a continuous perfusion process with CHO-K1 cells.
This study addressed the challenge of optimizing process parameters to achieve high cell densities and sustained productivity while ensuring scalability and product quality.
The results demonstrate HIP CHO Medium’s capability to enable efficient, scalable mAb manufacturing. Download the whitepaper to learn how this innovative solution can enhance your bioproduction efficiency.
Successfully scaling up a mAb process with Gibco High-Intensity Perfusion (HIP) CHO Medium
In a collaborative study with ZHAW using a continuous perfusion process with CHO-K1 cells, we evaluated the performance of the HIP CHO medium at two scales.
Here we address the challenges that arise when trying to get to market sooner with a perfusion process, identifying the optimal catalog media to allow you to quickly and efficiently establish a process.
The study highlights the medium's ability to support high cell densities and sustained productivity, making it ideal for efficient and scalable mAb manufacturing.
Contact us for more information
We offer a full array of innovative performance products and knowledge-based services, including fast and flexible cell line development, media and feeds, class-setting technologies, quality custom media development, and media optimizing services. We look forward to talking to you about your biomanufacturing needs.
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