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Invitrogen
ER Beta Recombinant Protein, Ligand Binding Domain, GST Tag Recombinant Protein
产品信息
A15665
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
244-530
标签
GST-tag
分类
Recombinant
类型
Protein
纯度
98% by SDS-PAGE
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris HCl, pH 8, with 0.5mM EDTA, 5mM DTT, 500mM KCl, 20% glycerol, 0.02% NP-40
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
This Estrogen Receptor (ER) Beta Ligand Binding Domain (LBD) is a 59.50 kDa recombinant human protein (amino acids 244-530) expressed as a GST fusion protein in baculovirus-infected insect cells. It was expressed and purified in the absence of exogenous ligands.
ER Beta-LBD recombinant protein is:
• Flexible—ideal for ligand binding and coregulator displacement assays developed in-house or partnered with our LanthaScreen™ ER Beta Coacvitator Assay Kit
• Ready to use—active, purified, and tagged with GST
• Convenient—available in bulk sizes
ER Beta-LBD recombinant protein is manufactured under the strictest quality parameters. This product is guaranteed for 6 months after purchase. Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond.
Used in:
LanthaScreen™ TR-FRET ER Beta Coactivator Assay Kit
For bulk reagents, email: !Mad-DiscoveryServices@lifetech.com
Protein Form: Recombinant, Ligand Binding Domain
靶标信息
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
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生物信息学
蛋白别名: ER beta; ER-beta; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2
基因别名: ER-BETA; Erb; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2
UniProt ID: (Human) Q92731
Entrez Gene ID: (Human) 2100
