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产品信息
RP-88139
产品规格
种属
Human
Expression System
HEK293 cells
氨基酸序列
Human B7-H6, amino acids Met1-Ser262 (Accession # NP_001189368.1) with a C-terminal human IgG1 Fc region
标签
Fc-tag
分子量
53.4 kDa
分类
Recombinant
类型
Protein
纯度
>95% as determined by SDS-PAGE.
内毒素浓度
<1.0 EU/µg
活性
1.Measured by its binding ability in a functional ELISA. 2.Immobilized human NCR3 at 10 µg/mL (100 µL/well) can bind human B7-H6 (RP-88139), the EC50 of human B7-H6 is 20-100 ng/mL.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (800 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
靶标信息
B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B7 homolog 6; B7-H6; DKFZp686I21167; Natural cytotoxicity triggering receptor 3 ligand 1; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167
基因别名: B7-H6; B7H6; DKFZp686O24166; NCR3LG1
UniProt ID: (Human) Q68D85
Entrez Gene ID: (Human) 374383
