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产品信息
BMS313
应用
建议稀释比
已发表文章
产品规格
种属
Human
已发表种属
Not Applicable
Expression System
CHO cells
氨基酸序列
Human ICAM-1 recombinant protein is truncated at the ectodomain side of the beginning of the transmembrane region (472 amino acids)
分子量
82 kDa
分类
Recombinant
类型
Protein
纯度
>99% by SDS-PAGE
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
purified
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Description: Recombinant soluble ICAM-1 is produced in CHO cells and corresponds in structure with natural human circulating ICAM-1, truncated at the ectodomain side of the beginning of the transmembrane region (aa.472).
BMS313 is > 99% pure as demonstrated by SDS-gel electrophoresis.
Purity: >99%.
Molecular Weight: 82.0 kDa.
靶标信息
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM-1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Ly 47; Major group rhinovirus receptor; MALA2; sCD54; soluble CD54; Surface antigen of activated B cells
基因别名: BB2; CD54; ICAM1; P3.58
UniProt ID: (Human) P05362
Entrez Gene ID: (Human) 3383
