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Human IL-13, Animal-Free Recombinant Protein, PeproTech®

Human IL-13, Animal-Free Protein in Functional Assay (Functional)

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Human IL-13, Animal-Free Protein (AF-200-13-10UG) in Functional

Bioassay analysis of Human IL-13, Animal-Free Recombinant Protein, PeproTech® (Product # AF-200-13-1MG).

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产品信息

AF-200-13-10UG

应用

建议稀释比

已发表文章

功能检测 (Functional)

Assay-dependent

体外检测 (IV)

查看7篇已发表文章 7篇已发表文章

其他PubMed (Misc)

查看1篇已发表文章 1篇已发表文章

产品规格

种属

Human

已发表种属

Human, Mouse

Expression System

E. coli

氨基酸序列

MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN

分子量

12.6 kDa

分类

Recombinant

类型

Protein

纯度

≥ 98% by SDS-PAGE gel and HPLC analyses.

内毒素浓度

<0.1 EU/µg

活性

Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤1.0 ng/ml, corresponding to a specific activity of ≥1 x 10^6 units/mg.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

purified

内含物

no preservative

保存条件

-20°C

运输条件

Ambient

产品详细信息

Recombinant Human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

靶标信息

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

USP24 promotes drug resistance during cancer therapy.

Cell death and differentiation

Wang SA,Young MJ,Wang YC,Chen SH,Liu CY,Lo YA,Jen HH,Hsu KC,Hung JJ

Wed Sep 01 00:00:00 EDT 2021

Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis.

The American journal of pathology

Ganieva U,Nakamura T,Osuka S,Nakanishi N,Kasahara Y,Takasaki N,Muraoka A,Hayashi S,Nagai T,Murase T,Goto M,Iwase A,Kikkawa F

AF-200-13 was used in In vitro experiments to study whether transcription factor 21 (TCF21) is involved in the development of endometriosis as an upstream regulatory gene of periostin.

Wed Jan 01 00:00:00 EST 2020

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.

Cell reports

Di Mitri D,Mirenda M,Vasilevska J,Calcinotto A,Delaleu N,Revandkar A,Gil V,Boysen G,Losa M,Mosole S,Pasquini E,D'Antuono R,Masetti M,Zagato E,Chiorino G,Ostano P,Rinaldi A,Gnetti L,Graupera M,Martins Figueiredo Fonseca AR,Pereira Mestre R,Waugh D,Barry S,De Bono J,Alimonti A

AF-200-13 was used in Cell Culture to identify tumor-associated macrophages as targets in prostate cancer and describe a therapeutic strategy based on CXCR2 blockade to harness anti-tumorigenic potential of macrophages against this disease.

Tue Aug 20 00:00:00 EDT 2019

Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.

The Journal of biological chemistry

Buzza MS,Johnson TA,Conway GD,Martin EW,Mukhopadhyay S,Shea-Donohue T,Antalis TM

Fri Jun 30 00:00:00 EDT 2017

Periostin promotes chronic allergic inflammation in response to Th2 cytokines.

The Journal of clinical investigation

Masuoka M,Shiraishi H,Ohta S,Suzuki S,Arima K,Aoki S,Toda S,Inagaki N,Kurihara Y,Hayashida S,Takeuchi S,Koike K,Ono J,Noshiro H,Furue M,Conway SJ,Narisawa Y,Izuhara K

Sun Jul 01 00:00:00 EDT 2012

IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.

The Journal of clinical investigation

Alevy YG,Patel AC,Romero AG,Patel DA,Tucker J,Roswit WT,Miller CA,Heier RF,Byers DE,Brett TJ,Holtzman MJ

Sat Dec 01 00:00:00 EST 2012

Activation of STAT6 by STING is critical for antiviral innate immunity.

Cell

Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

Fri Oct 14 00:00:00 EDT 2011

High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.

PloS one

Maharjan AS,Pilling D,Gomer RH

Fri Feb 17 00:00:00 EST 2012

生物信息学

蛋白别名: ALRH; ALRH antibody; BHR1; il 13; IL-13; ILN; Interleukin; Interleukin-13; Interleukin13; MGC116786; MGC116788; MGC116789; NC30 antibody; P600 antibody

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基因别名: IL-13; IL13; NC30; P600

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UniProt ID: (Human) P35225

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Entrez Gene ID: (Human) 3596

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Human IL-13, Animal-Free Recombinant Protein, PeproTech®

Human IL-13, Animal-Free Protein (AF-200-13-10UG) in Functional

产品信息

AF-200-13-10UG

功能检测 (Functional)

体外检测 (IV)

其他PubMed (Misc)

种属

已发表种属

Expression System

氨基酸序列

分子量

分类

类型

纯度

内毒素浓度

活性

偶联物

形式

纯化类型

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

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