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产品信息
PHC9151
应用
建议稀释比
已发表文章
产品规格
种属
Human
已发表种属
Human
Expression System
E. coli
氨基酸序列
Human IL-15 recombinant protein contains 115 amino acids
分子量
12.9 kDa
分类
Recombinant
类型
Protein
纯度
≥98% by SDS-PAGE
内毒素浓度
<1 EU/mL
活性
ED50 ≤ 0.5 ng/mL; determined by the dose-dependent proliferation of CTLL-2 cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
Carrier-Free
Reconstitution: We recommend reconstituting the lyophilized protein in sterile double distilled water containing at least 0.1% human serum albumin or bovine serum albumin to prepare a stock solution of ≥1 mg/mL of the protein. The reconstituted protein should be apportioned into working aliquots and stored at ≤-20°C.
Storage: The lyophilized protein is stable for a few weeks at room temperature, but is best stored at -20°C. Reconstituted human IL-15 should be stored at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.
靶标信息
IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: il 15; IL-15; ILN; Interleukin; Interleukin-15; Interleukin15; M-IL-15; MGC9721
基因别名: IL-15; IL15
UniProt ID: (Human) P40933
Entrez Gene ID: (Human) 3600
