Product References
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Cell
Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR
Thu May 28 00:00:00 EDT 2020
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
Thu Aug 06 00:00:00 EDT 2020
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
Thu Aug 06 00:00:00 EDT 2020
Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells.
The Journal of clinical investigation
Xie CB,Jiang B,Qin L,Tellides G,Kirkiles-Smith NC,Jane-Wit D,Pober JS
Wed Jul 01 00:00:00 EDT 2020
Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats.
CNS neuroscience & therapeutics
Wang QS,Ding HG,Chen SL,Liu XQ,Deng YY,Jiang WQ,Li Y,Huang LQ,Han YL,Wen MY,Wang MQ,Zeng HK
Thu Oct 01 00:00:00 EDT 2020
LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes.
Frontiers in immunology
Sohrabi Y,Sonntag GVH,Braun LC,Lagache SMM,Liebmann M,Klotz L,Godfrey R,Kahles F,Waltenberger J,Findeisen HM
200-01RA was used in Sample Preparation to analyse the role of Liver X Receptor (LXR), a key regulator of cholesterol and fatty acid homeostasis, in trained innate immunity.
Mon Mar 15 00:00:00 EDT 2021
An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.
Cancer research
Carter BZ,Mak PY,Wang X,Tao W,Ruvolo V,Mak D,Mu H,Burks JK,Andreeff M
200-01RA was used in Cell Culture to conclude that the antiapoptotic protein ARC promotes AML aggressiveness by enabling detrimental cross-talk with bone marrow mesenchymal stromal cells.
Fri Mar 15 00:00:00 EDT 2019
VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages.
Science advances
Huang X,Feng Z,Jiang Y,Li J,Xiang Q,Guo S,Yang C,Fei L,Guo G,Zheng L,Wu Y,Chen Y
200-01RA was used in In vivo experiments to investigate signaling factors contributing to NLRP3 inflammosome hyper activation.
Tue Jan 01 00:00:00 EST 2019
M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling.
Frontiers in immunology
Zong Z,Zou J,Mao R,Ma C,Li N,Wang J,Wang X,Zhou H,Zhang L,Shi Y
200-01RA was used in In vitro experiments to demonstrate that M1 macrophages induced expression of PD-L1 in HCC cells, supporting the pro-tumor role of M1 macrophages.
Wed Oct 14 00:00:00 EDT 2020
Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt.
Scientific reports
Dang T,Liou GY
Wed May 16 00:00:00 EDT 2018
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Nature communications
Iriondo O,Liu Y,Lee G,Elhodaky M,Jimenez C,Li L,Lang J,Wang P,Yu M
Fri May 18 00:00:00 EDT 2018
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Nature communications
Iriondo O,Liu Y,Lee G,Elhodaky M,Jimenez C,Li L,Lang J,Wang P,Yu M
Fri May 18 00:00:00 EDT 2018
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.
The Journal of clinical investigation
Leaf IA,Nakagawa S,Johnson BG,Cha JJ,Mittelsteadt K,Guckian KM,Gomez IG,Altemeier WA,Duffield JS
200-01RA was used in Cell Culture to show that in pericytes, MyD88 and IRAK4 are key regulators of 2 major injury responses: inflammatory and fibrogenic.
Tue Jan 03 00:00:00 EST 2017
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.
The Journal of clinical investigation
Leaf IA,Nakagawa S,Johnson BG,Cha JJ,Mittelsteadt K,Guckian KM,Gomez IG,Altemeier WA,Duffield JS
200-01RA was used in Cell Culture to show that in pericytes, MyD88 and IRAK4 are key regulators of 2 major injury responses: inflammatory and fibrogenic.
Tue Jan 03 00:00:00 EST 2017
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
The Journal of experimental medicine
Young HL,Rowling EJ,Bugatti M,Giurisato E,Luheshi N,Arozarena I,Acosta JC,Kamarashev J,Frederick DT,Cooper ZA,Reuben A,Gil J,Flaherty KT,Wargo JA,Vermi W,Smith MP,Wellbrock C,Hurlstone A
Mon Jun 05 00:00:00 EDT 2017
α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.
Journal of immunology (Baltimore, Md. : 1950)
Falahee PC,Anderson LS,Reynolds MB,Pirir M,McLaughlin BE,Dillen CA,Cheung AL,Miller LS,Simon SI
Fri Sep 01 00:00:00 EDT 2017
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
The Journal of clinical investigation
Spalinger MR,Kasper S,Gottier C,Lang S,Atrott K,Vavricka SR,Scharl S,Raselli T,Frey-Wagner I,Gutte PM,Grütter MG,Beer HD,Contassot E,Chan AC,Dai X,Rawlings DJ,Mair F,Becher B,Falk W,Fried M,Rogler G,Scharl M
Mon May 02 00:00:00 EDT 2016
IL-1β induces hypomyelination in the periventricular white matter through inhibition of oligodendrocyte progenitor cell maturation via FYN/MEK/ERK signaling pathway in septic neonatal rats.
Glia
Xie D,Shen F,He S,Chen M,Han Q,Fang M,Zeng H,Chen C,Deng Y
200-01RA was used in Cell Culture to suggest that following LPS injection, microglia are activated and produce IL-1β in the PWM in the neonatal rats.
Fri Apr 01 00:00:00 EDT 2016
Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.
Proceedings of the National Academy of Sciences of the United States of America
Prieto GA,Snigdha S,Baglietto-Vargas D,Smith ED,Berchtold NC,Tong L,Ajami D,LaFerla FM,Rebek J,Cotman CW
Tue Sep 08 00:00:00 EDT 2015
Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance.
Blood
Jacamo R,Chen Y,Wang Z,Ma W,Zhang M,Spaeth EL,Wang Y,Battula VL,Mak PY,Schallmoser K,Ruvolo P,Schober WD,Shpall EJ,Nguyen MH,Strunk D,Bueso-Ramos CE,Konoplev S,Davis RE,Konopleva M,Andreeff M
Thu Apr 24 00:00:00 EDT 2014
Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.
Journal of immunology (Baltimore, Md. : 1950)
Eigenbrod T,Bode KA,Dalpke AH
Sat Jun 15 00:00:00 EDT 2013
Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.
Proceedings of the National Academy of Sciences of the United States of America
Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM
Tue Jan 31 00:00:00 EST 2012
Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1.
PLoS pathogens
Unger BL,Faris AN,Ganesan S,Comstock AT,Hershenson MB,Sajjan US
Thu Apr 04 00:00:00 EDT 2013
Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1.
PLoS pathogens
Unger BL,Faris AN,Ganesan S,Comstock AT,Hershenson MB,Sajjan US
Thu Apr 04 00:00:00 EDT 2013
Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1.
PLoS pathogens
Unger BL,Faris AN,Ganesan S,Comstock AT,Hershenson MB,Sajjan US
Thu Apr 04 00:00:00 EDT 2013
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
PloS one
Iyer A,Zurolo E,Prabowo A,Fluiter K,Spliet WG,van Rijen PC,Gorter JA,Aronica E
Tue Mar 05 00:00:00 EST 2013
Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury.
Molecular pain
Chai B,Guo W,Wei F,Dubner R,Ren K
Tue Oct 23 00:00:00 EDT 2012
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
Journal of neuroinflammation
Green JA,Dholakia S,Janczar K,Ong CW,Moores R,Fry J,Elkington PT,Roncaroli F,Friedland JS
Wed May 11 00:00:00 EDT 2011
DNA damage-mediated induction of a chemoresistant niche.
Cell
Gilbert LA,Hemann MT
Fri Oct 29 00:00:00 EDT 2010
Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.
Journal of immunology (Baltimore, Md. : 1950)
Green JA,Elkington PT,Pennington CJ,Roncaroli F,Dholakia S,Moores RC,Bullen A,Porter JC,Agranoff D,Edwards DR,Friedland JS
Tue Jun 01 00:00:00 EDT 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 EDT 2010
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.
Journal of neurotrauma
Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ
Wed Apr 01 00:00:00 EDT 2009
Monocyte-dependent fibroblast CXCL8 secretion occurs in tuberculosis and limits survival of mycobacteria within macrophages.
Journal of immunology (Baltimore, Md. : 1950)
O'Kane CM,Boyle JJ,Horncastle DE,Elkington PT,Friedland JS
Thu Mar 15 00:00:00 EDT 2007
Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy.
The Journal of biological chemistry
Serantes R,Arnalich F,Figueroa M,Salinas M,Andrés-Mateos E,Codoceo R,Renart J,Matute C,Cavada C,Cuadrado A,Montiel C
Fri May 26 00:00:00 EDT 2006
Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.
American journal of respiratory and critical care medicine
Morris GE,Whyte MK,Martin GF,Jose PJ,Dower SK,Sabroe I
Fri Apr 15 00:00:00 EDT 2005
Monocyte-astrocyte networks and the regulation of chemokine secretion in neurocysticercosis.
Journal of immunology (Baltimore, Md. : 1950)
Uddin J,Garcia HH,Gilman RH,Gonzalez AE,Friedland JS
Thu Sep 01 00:00:00 EDT 2005
Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis.
The Journal of biological chemistry
Wickremasinghe MI,Thomas LH,O'Kane CM,Uddin J,Friedland JS
Fri Jun 25 00:00:00 EDT 2004
Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cartmell T,Southgate T,Rees GS,Castro MG,Lowenstein PR,Luheshi GN
Mon Feb 15 00:00:00 EST 1999
