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产品信息
PEP-0904
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 12 amino acids near the carboxy terminus of human IRGC.
PEP-0904 can be used as a blocking peptide with polyclonal antibody PA5-20790.
靶标信息
Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
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生物信息学
蛋白别名: cinema 1; Immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon-gamma-inducible GTPase IFGGE protein; Interferon-inducible GTPase 5
基因别名: CINEMA; IFGGE; IIGP5; IRGC; IRGC1; R30953_1
UniProt ID: (Human) Q6NXR0
Entrez Gene ID: (Human) 56269
