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产品信息
PV4657
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
207-447
标签
GST-tag
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
LXR-a (Liver X Receptor alpha) ligand binding domain is a 55.9 kDa recombinant human protein (amino acids 207-447) expressed as a GST fusion protein in baculovirus-infected insect cells. LXR alpha was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Protein Form: Recombinant, Ligand Binding Domain
靶标信息
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXRb; NER; NERI; NR1H2; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha
基因别名: LXR-a; LXRA; NR1H3; RLD-1
UniProt ID: (Human) Q13133
Entrez Gene ID: (Human) 10062
