Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Application
图: 1 / 1
Human MMP-24 Protein (RP-77536) in SDS-PAGE
SDS-PAGE of 2 µg MT5-MMP catalytic domain (Product # RP-77536).
产品信息
RP-77536
产品规格
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
RP-77536 is a purified recombinant MMP-24 (catalytic domain) protein purified from E. coli periplasm. MT5-MMP catalytic domain is produced by activation of a recombinant soluble proform of MT5-MMP. Activation generates two molecular species. One species begins at the N-terminus with Tyr156 of full-length MT5-MMP, while the other species is two amino acid residues shorter and starts with Leu158. Both species extend to Ser351 of MT5-MMP.
靶标信息
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell-matrix interactions. MMPs are Zn (2+)-binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
