Gibco

Human Oncostatin M (227 aa) Recombinant Protein, PeproTech®

产品信息

300-10-10UG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

功能检测 (Functional)

Assay-dependent

体外检测 (IV)

查看57篇已发表文章 57篇已发表文章

其他PubMed (Misc)

查看6篇已发表文章 6篇已发表文章

产品规格

种属

Human

已发表种属

Dog, Human, Mouse, Non-human primate, Rat

Expression System

E. coli

氨基酸序列

AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR

分子量

25.7 kDa

分类

Recombinant

类型

Protein

纯度

≥ 98% by SDS-PAGE gel and HPLC analyses.

内毒素浓度

<1 EU/µg

活性

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

purified

内含物

no preservative

保存条件

-20°C

运输条件

Ambient

产品详细信息

Recombinant Human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues (full length precursor).

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

靶标信息

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

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STAR protocols

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Current protocols in stem cell biology

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Fri Aug 01 00:00:00 EDT 2014

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