Product References
Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration.
iScience
Liu F,Lin Q,Shen S,Li Z,Xie X,Cheng Q,Wang L,Long Y,Wang J,Liu L
120-38 was used in In vitro experiments to design an extracellular matrix (ECM)-adhesion mimic hydrogel for intrauterine administration, which was more effective than direct injection in treating intrauterine adhesions.
Fri Jun 21 00:00:00 EDT 2024
Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation.
Nature communications
Molinuevo R,Menendez J,Cadle K,Ariqat N,Choy MK,Lagousis C,Thomas G,Strietzel C,Bubolz JW,Hinck L
120-38 was used in Tissue/organ culture to show that DNA damage accumulates due to replication stress during pregnancy, activating the DNA damage response.
Wed Apr 17 00:00:00 EDT 2024
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
120-38 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 EDT 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
120-38 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 EDT 2023
Initial Characterization of 3D Culture of Yolk Sac Tissue.
Animals : an open access journal from MDPI
Pereira VM,Pinto PAF,Motta LCB,Almeida MF,de Andrade AFC,Pavaneli APP,Ambrósio CE
120-38 was used in Cell Culture to standardise 3D culture techniques for the yolk sac in three domestic species (porcine, canine, and bovine) models.
Sat Apr 22 00:00:00 EDT 2023
The preference for sugar over sweetener depends on a gut sensor cell.
Nature neuroscience
Buchanan KL,Rupprecht LE,Kaelberer MM,Sahasrabudhe A,Klein ME,Villalobos JA,Liu WW,Yang A,Gelman J,Park S,Anikeeva P,Bohórquez DV
Tue Feb 01 00:00:00 EST 2022
Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer.
American journal of human genetics
Nakamura K,Reid BM,Chen A,Chen Z,Goode EL,Permuth JB,Teer JK,Tyrer J,Yu X,Kanetsky PA,Pharoah PD,Gayther SA,Sellers TA,Lawrenson K,Karreth FA
120-38 was used in In vitro experiments to integrate in silico variant-to-function analysis with functional studies to characterize the oncogenic potential of candidate genes in the 1p34.3 locus.
Thu Jan 06 00:00:00 EST 2022
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips.
Lab on a chip
Grant J,Lee E,Almeida M,Kim S,LoGrande N,Goyal G,Sesay AM,Breault DT,Prantil-Baun R,Ingber DE
120-38 was used in Sample Preparation to describe a simple strategy which recapitulates in vivo functionality to achieve physiologically relevant oxygen tension in a two-channel human small intestine-on-a-chip (Intestine Chip) lined with primary human duodenal epithelium and intestinal microvascular endothelium in parallel channels separated by a porous membrane while both channels are perfused with oxygenated medium.
Tue Apr 12 00:00:00 EDT 2022
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation.
The Journal of experimental medicine
Chaves-Pérez A,Santos-de-Frutos K,de la Rosa S,Herranz-Montoya I,Perna C,Djouder N
120-38 was used in In vitro experiments to demonstrate that transit-amplifying (TA) cells, marked by unconventional prefoldin RPB5 interactor (URI), control R-spondin production to guide ISC proliferation.
Mon Nov 07 00:00:00 EST 2022
In-Depth Comparison of Matrigel Dissolving Methods on Proteomic Profiling of Organoids.
Molecular & cellular proteomics : MCP
Wang M,Yu H,Zhang T,Cao L,Du Y,Xie Y,Ji J,Wu J
Sat Jan 01 00:00:00 EST 2022
Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus.
Frontiers in cellular and infection microbiology
Ekanger CT,Zhou F,Bohan D,Lotsberg ML,Ramnefjell M,Hoareau L,Røsland GV,Lu N,Aanerud M,Gärtner F,Salminen PR,Bentsen M,Halvorsen T,Ræder H,Akslen LA,Langeland N,Cox R,Maury W,Stuhr LEB,Lorens JB,Engelsen AST
120-38 was used in Immunohistochemistry to investigate virulent affects of SARS-CoV-2 mutations on organoid models.
Tue Apr 05 00:00:00 EDT 2022
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.
Cell stem cell
Karvas RM,Khan SA,Verma S,Yin Y,Kulkarni D,Dong C,Park KM,Chew B,Sane E,Fischer LA,Kumar D,Ma L,Boon ACM,Dietmann S,Mysorekar IU,Theunissen TW
120-38 was used in Cell Culture to demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors.
Thu May 05 00:00:00 EDT 2022
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Cell
Koikawa K,Kibe S,Suizu F,Sekino N,Kim N,Manz TD,Pinch BJ,Akshinthala D,Verma A,Gaglia G,Nezu Y,Ke S,Qiu C,Ohuchida K,Oda Y,Lee TH,Wegiel B,Clohessy JG,London N,Santagata S,Wulf GM,Hidalgo M,Muthuswamy SK,Nakamura M,Gray NS,Zhou XZ,Lu KP
Thu Sep 02 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Mon Apr 05 00:00:00 EDT 2021
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis.
Frontiers in oncology
Yan Z,Qu J,Li Z,Yi J,Su Y,Lin Q,Yu G,Lin Z,Yin W,Lu F,Liu J
120-38 was used in Cell Culture to indicate that NEK7 promotes pancreatic cancer progression and it may be a potential marker for PDAC prognosis.
Sat Jul 24 00:00:00 EDT 2021
Repositioning of duloxetine to target pancreatic stellate cells.
Oncology letters
Sagara A,Nakata K,Matsumoto S,Guan W,Shinkawa T,Iwamoto C,Ikenaga N,Ohuchida K,Nakamura M
120-38 was used in Tissue/organ culture to suggest that duloxetine may be a potential drug for suppressing PSC activation and pancreatic cancer growth.
Fri Oct 01 00:00:00 EDT 2021
Characterization of an in vitro 3D intestinal organoid model by using massive RNAseq-based transcriptome profiling.
Scientific reports
Lu J,Krepelova A,Rasa SMM,Annunziata F,Husak O,Adam L,Nunna S,Neri F
Tue Aug 17 00:00:00 EDT 2021
Multiplexed single-cell analysis of organoid signaling networks.
Nature protocols
Sufi J,Qin X,Rodriguez FC,Bu YJ,Vlckova P,Zapatero MR,Nitz M,Tape CJ
Fri Oct 01 00:00:00 EDT 2021
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ.
Nature communications
Della Chiara G,Gervasoni F,Fakiola M,Godano C,D'Oria C,Azzolin L,Bonnal RJP,Moreni G,Drufuca L,Rossetti G,Ranzani V,Bason R,De Simone M,Panariello F,Ferrari I,Fabbris T,Zanconato F,Forcato M,Romano O,Caroli J,Gruarin P,Sarnicola ML,Cordenonsi M,Bardelli A,Zucchini N,Ceretti AP,Mariani NM,Cassingena A,Sartore-Bianchi A,Testa G,Gianotti L,Opocher E,Pisati F,Tripodo C,Macino G,Siena S,Bicciato S,Piccolo S,Pagani M
Tue Apr 20 00:00:00 EDT 2021
Protocol for establishing organoids from human ovarian cancer biopsies.
STAR protocols
Maenhoudt N,Vankelecom H
120-38 was used in Cell Culture to provide a detailed protocol for establishing organoid cultures from patient OC biopsies.
Fri Jun 18 00:00:00 EDT 2021
Phosphorylation-induced changes in the PDZ domain of Dishevelled 3.
Scientific reports
Jurásek M,Kumar J,Paclíková P,Kumari A,Tripsianes K,Bryja V,Vácha R
Fri Jan 15 00:00:00 EST 2021
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Life (Basel, Switzerland)
Liu LM,Tang Q,Hu X,Zhao JJ,Zhang Y,Ying GG,Zhang F
120-38 was used in Cell Culture to show that p53 function is regulated by PRMT1 in breast cancer cells.
Thu Aug 05 00:00:00 EDT 2021
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.
eLife
Radaszkiewicz T,Nosková M,Gömöryová K,Vondálová Blanářová O,Radaszkiewicz KA,Picková M,Víchová R,Gybe¿ T,Kaiser K,Demková L,Kučerová L,Bárta T,Potěšil D,Zdráhal Z,Souček K,Bryja V
120-38 was used in In vitro experiments to conclude that RNF43 is a newly discovered negative regulator of WNT5A-mediated biological responses that desensitizes cells to WNT5A.
Wed Oct 27 00:00:00 EDT 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
120-38 was used in Tissue/organ culture to show that inhibition of PHGDH, the first step in the SSP, cooperates with serine and glycine depletion to inhibit one-carbon metabolism and cancer growth.
Thu Jan 14 00:00:00 EST 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Nature communications
Tajan M,Hennequart M,Cheung EC,Zani F,Hock AK,Legrave N,Maddocks ODK,Ridgway RA,Athineos D,Suárez-Bonnet A,Ludwig RL,Novellasdemunt L,Angelis N,Li VSW,Vlachogiannis G,Valeri N,Mainolfi N,Suri V,Friedman A,Manfredi M,Blyth K,Sansom OJ,Vousden KH
120-38 was used in Tissue/organ culture to show that inhibition of PHGDH, the first step in the SSP, cooperates with serine and glycine depletion to inhibit one-carbon metabolism and cancer growth.
Thu Jan 14 00:00:00 EST 2021
Establishment of patient-derived organotypic tumor spheroid models for tumor microenvironment modeling.
Cancer medicine
Hong HK,Yun NH,Jeong YL,Park J,Doh J,Lee WY,Cho YB
Sun Aug 01 00:00:00 EDT 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 EST 2021
Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium.
Journal of personalized medicine
Francés-Herrero E,Juárez-Barber E,Campo H,López-Martínez S,de Miguel-Gómez L,Faus A,Pellicer A,Ferrero H,Cervelló I
Thu Jun 03 00:00:00 EDT 2021
Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua.
Cell reports
Cheung VC,Peng CY,Marinić M,Sakabe NJ,Aneas I,Lynch VJ,Ober C,Nobrega MA,Kessler JA
Tue May 18 00:00:00 EDT 2021
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.
Cell stem cell
Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JC
120-38 was used in Tissue/organ culture to show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation.
Thu Jun 04 00:00:00 EDT 2020
Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Cell stem cell
Li Q,Sun Y,Jarugumilli GK,Liu S,Dang K,Cotton JL,Xiol J,Chan PY,DeRan M,Ma L,Li R,Zhu LJ,Li JH,Leiter AB,Ip YT,Camargo FD,Luo X,Johnson RL,Wu X,Mao J
120-38 was used in Tissue/organ culture to demonstrate if Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intestinal stem cells.
Thu May 07 00:00:00 EDT 2020
The Sca-1+ and Sca-1- mouse prostatic luminal cell lineages are independently sustained.
Stem cells (Dayton, Ohio)
Kwon OJ,Choi JM,Zhang L,Jia D,Li Z,Zhang Y,Jung SY,Creighton CJ,Xin L
Sun Nov 01 00:00:00 EDT 2020
Maturation of human intestinal organoids in vitro facilitates colonization by commensal lactobacilli by reinforcing the mucus layer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Son YS,Ki SJ,Thanavel R,Kim JJ,Lee MO,Kim J,Jung CR,Han TS,Cho HS,Ryu CM,Kim SH,Park DS,Son MY
Sat Aug 01 00:00:00 EDT 2020
LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma.
Cell death & disease
Chang TH,Shanti RM,Liang Y,Zeng J,Shi S,Alawi F,Carrasco L,Zhang Q,Le AD
Thu May 07 00:00:00 EDT 2020
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Nature communications
Grinat J,Heuberger J,Vidal RO,Goveas N,Kosel F,Berenguer-Llergo A,Kranz A,Wulf-Goldenberg A,Behrens D,Melcher B,Sauer S,Vieth M,Batlle E,Stewart AF,Birchmeier W
Mon Dec 21 00:00:00 EST 2020
R-spondins are BMP receptor antagonists in Xenopus early embryonic development.
Nature communications
Lee H,Seidl C,Sun R,Glinka A,Niehrs C
Wed Nov 04 00:00:00 EST 2020
R-spondins are BMP receptor antagonists in Xenopus early embryonic development.
Nature communications
Lee H,Seidl C,Sun R,Glinka A,Niehrs C
Wed Nov 04 00:00:00 EST 2020
NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype.
Oncoimmunology
Marcon F,Zuo J,Pearce H,Nicol S,Margielewska-Davies S,Farhat M,Mahon B,Middleton G,Brown R,Roberts KJ,Moss P
120-38 was used in Cell Culture to analyze the phenotype and function of natural killer (NK) cells in the blood and in tumor tissue from patients with pancreatic ductal adenocarcinoma (PDAC).
Thu Nov 19 00:00:00 EST 2020
A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses.
Redox biology
Okkelman IA,Neto N,Papkovsky DB,Monaghan MG,Dmitriev RI
120-38 was used in Tissue/organ culture to study the redox metabolism of Lgr5-GFP intestinal organoids by combined analysis of fluorescence-based FLIM for NAD(P)H and organoid oxygenation by phosphorescence-based PLIM,.
Sat Feb 01 00:00:00 EST 2020
Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.
Cell death & disease
Seiwert N,Wecklein S,Demuth P,Hasselwander S,Kemper TA,Schwerdtle T,Brunner T,Fahrer J
Wed Sep 23 00:00:00 EDT 2020
Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK Activation.
Cellular and molecular gastroenterology and hepatology
Sheng W,Malagola E,Nienhüser H,Zhang Z,Kim W,Zamechek L,Sepulveda A,Hata M,Hayakawa Y,Zhao CM,Chen D,Wang TC
120-38 was used in Cell Culture to study the genes involved in the mechanisms that lead to hypergastrinemia in enterochromaffin-like cells.
Fri Jul 09 00:00:00 EDT 2021
Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells.
Nature communications
Fu DJ,Wang L,Chouairi FK,Rose IM,Abetov DA,Miller AD,Yamulla RJ,Schimenti JC,Flesken-Nikitin A,Nikitin AY
Fri Jan 03 00:00:00 EST 2020
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Cell
Wang H,Xiang D,Liu B,He A,Randle HJ,Zhang KX,Dongre A,Sachs N,Clark AP,Tao L,Chen Q,Botchkarev VV,Xie Y,Dai N,Clevers H,Li Z,Livingston DM
Thu Jun 27 00:00:00 EDT 2019
Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.
The Journal of clinical investigation
Meir M,Burkard N,Ungewiß H,Diefenbacher M,Flemming S,Kannapin F,Germer CT,Schweinlin M,Metzger M,Waschke J,Schlegel N
Mon Jun 17 00:00:00 EDT 2019
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function.
The Journal of experimental medicine
Volk JK,Nyström EEL,van der Post S,Abad BM,Schroeder BO,Johansson Å,Svensson F,Jäverfelt S,Johansson MEV,Hansson GC,Birchenough GMH
Mon Nov 04 00:00:00 EST 2019
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Oncogene
Wagner S,Vlachogiannis G,De Haven Brandon A,Valenti M,Box G,Jenkins L,Mancusi C,Self A,Manodoro F,Assiotis I,Robinson P,Chauhan R,Rust AG,Matthews N,Eason K,Khan K,Starling N,Cunningham D,Sadanandam A,Isacke CM,Kirkin V,Valeri N,Whittaker SR
Fri Mar 01 00:00:00 EST 2019
Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11.
American journal of physiology. Cell physiology
Katsumi T,Guicciardi ME,Azad A,Bronk SF,Krishnan A,Gores GJ
Tue Oct 01 00:00:00 EDT 2019
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro.
Nature communications
Feldman A,Mukha D,Maor II,Sedov E,Koren E,Yosefzon Y,Shlomi T,Fuchs Y
Tue May 28 00:00:00 EDT 2019
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nature communications
Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rashid ST
Fri Jul 26 00:00:00 EDT 2019
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration.
Nature communications
Liu M,Sun T,Li N,Peng J,Fu D,Li W,Li L,Gao WQ
Thu Oct 10 00:00:00 EDT 2019
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Nature communications
Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N
Tue Nov 26 00:00:00 EST 2019
A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Life science alliance
Heuberger J,Hill U,Förster S,Zimmermann K,Malchin V,Kühl AA,Stein U,Vieth M,Birchmeier W,Leutz A
120-38 was used in Cell Culture to suggest homeostatic and oncogenic suppressor functions of C/EBPα in the gut by restricting Wnt signaling.
Fri Feb 01 00:00:00 EST 2019
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.
Cell
Kinchen J,Chen HH,Parikh K,Antanaviciute A,Jagielowicz M,Fawkner-Corbett D,Ashley N,Cubitt L,Mellado-Gomez E,Attar M,Sharma E,Wills Q,Bowden R,Richter FC,Ahern D,Puri KD,Henault J,Gervais F,Koohy H,Simmons A
Thu Oct 04 00:00:00 EDT 2018
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan DA,Zinzalla V,Moll J,Boj SF,Voest EE,Wessels L,van Diest PJ,Rottenberg S,Vries RGJ,Cuppen E,Clevers H
Thu Jan 11 00:00:00 EST 2018
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.
Cancer discovery
Hill SJ,Decker B,Roberts EA,Horowitz NS,Muto MG,Worley MJ,Feltmate CM,Nucci MR,Swisher EM,Nguyen H,Yang C,Morizane R,Kochupurakkal BS,Do KT,Konstantinopoulos PA,Liu JF,Bonventre JV,Matulonis UA,Shapiro GI,Berkowitz RS,Crum CP,D'Andrea AD
120-38 was used in Tissue/organ culture to demonstrate a platform for functional profiling of DNA repair in short-term patient-derived high-grade serous ovarian cancer (HGSC) organoids as a means of assessing targetable defects in the parent tumors, offering more suitable treatment options.
Thu Nov 01 00:00:00 EDT 2018
Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3.
Proceedings of the National Academy of Sciences of the United States of America
Sechet E,Telford E,Bonamy C,Sansonetti PJ,Sperandio B
Tue Oct 16 00:00:00 EDT 2018
ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Nature communications
Koren E,Yosefzon Y,Ankawa R,Soteriou D,Jacob A,Nevelsky A,Ben-Yosef R,Bar-Sela G,Fuchs Y
Fri Nov 02 00:00:00 EDT 2018
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
Bayrer JR,Wang H,Nattiv R,Suzawa M,Escusa HS,Fletterick RJ,Klein OD,Moore DD,Ingraham HA
Wed Oct 10 00:00:00 EDT 2018
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
Bayrer JR,Wang H,Nattiv R,Suzawa M,Escusa HS,Fletterick RJ,Klein OD,Moore DD,Ingraham HA
Wed Oct 10 00:00:00 EDT 2018
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.
Scientific reports
Kasendra M,Tovaglieri A,Sontheimer-Phelps A,Jalili-Firoozinezhad S,Bein A,Chalkiadaki A,Scholl W,Zhang C,Rickner H,Richmond CA,Li H,Breault DT,Ingber DE
Tue Feb 13 00:00:00 EST 2018
Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.
Scientific reports
Shibata W,Kinoshita H,Hikiba Y,Sato T,Ishii Y,Sue S,Sugimori M,Suzuki N,Sakitani K,Ijichi H,Mori R,Endo I,Maeda S
Wed Apr 18 00:00:00 EDT 2018
Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta.
Stem cell reports
Haider S,Meinhardt G,Saleh L,Kunihs V,Gamperl M,Kaindl U,Ellinger A,Burkard TR,Fiala C,Pollheimer J,Mendjan S,Latos PA,Knöfler M
Tue Aug 14 00:00:00 EDT 2018
Expression of the human antimicrobial peptide β-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells.
Scientific reports
Bonamy C,Sechet E,Amiot A,Alam A,Mourez M,Fraisse L,Sansonetti PJ,Sperandio B
Fri Dec 21 00:00:00 EST 2018
Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system.
Scientific reports
Garnier D,Li R,Delbos F,Fourrier A,Collet C,Guguen-Guillouzo C,Chesné C,Nguyen TH
Tue May 29 00:00:00 EDT 2018
Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Nature
Sigal M,Logan CY,Kapalczynska M,Mollenkopf HJ,Berger H,Wiedenmann B,Nusse R,Amieva MR,Meyer TF
Thu Aug 24 00:00:00 EDT 2017
Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Nature
Sigal M,Logan CY,Kapalczynska M,Mollenkopf HJ,Berger H,Wiedenmann B,Nusse R,Amieva MR,Meyer TF
Thu Aug 24 00:00:00 EDT 2017
ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis.
The EMBO journal
Horiguchi H,Endo M,Kawane K,Kadomatsu T,Terada K,Morinaga J,Araki K,Miyata K,Oike Y
Wed Feb 15 00:00:00 EST 2017
The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells.
Molecular and cellular biology
Paclíková P,Bernatík O,Radaszkiewicz TW,Bryja V
120-38 was used in Cell Culture to provide evidence that DVL is indispensable for the phosphorylation of LRP6 and downstream signaling after activation by the Wnt3a ligand in mammalian cells.
Fri Sep 15 00:00:00 EDT 2017
Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions.
Cell chemical biology
Dietrich L,Rathmer B,Ewan K,Bange T,Heinrichs S,Dale TC,Schade D,Grossmann TN
120-38 was used in Tissue/organ culture to develop a stapled peptide inhibitor that targets the interaction between β-catenin and T cell factor/lymphoid enhancer-binding factor transcription factors, which are crucially involved in Wnt signaling.
Thu Aug 17 00:00:00 EDT 2017
Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein.
The Journal of biological chemistry
Zhang N,Huang H,Tan B,Wei Y,Xiong Q,Yan Y,Hou L,Wu N,Siwko S,Cimarelli A,Xu J,Han H,Qian M,Liu M,Du B
Fri Oct 06 00:00:00 EDT 2017
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 EDT 2016
Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge.
Proceedings of the National Academy of Sciences of the United States of America
Fischer N,Sechet E,Friedman R,Amiot A,Sobhani I,Nigro G,Sansonetti PJ,Sperandio B
Tue May 24 00:00:00 EDT 2016
Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential.
Stem cells (Dayton, Ohio)
Kwon OJ,Zhang L,Xin L
Fri Jan 01 00:00:00 EST 2016
Bridging the gap: functional healing of embryonic small intestine ex vivo.
Journal of tissue engineering and regenerative medicine
Coletta R,Roberts NA,Oltrabella F,Khalil BA,Morabito A,Woolf AS
Mon Feb 01 00:00:00 EST 2016
Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture.
Scientific reports
Anzai K,Chikada H,Tsuruya K,Ida K,Kagawa T,Inagaki Y,Mine T,Kamiya A
Thu Jun 23 00:00:00 EDT 2016
Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.
Nature communications
Jardé T,Lloyd-Lewis B,Thomas M,Kendrick H,Melchor L,Bougaret L,Watson PD,Ewan K,Smalley MJ,Dale TC
Wed Oct 26 00:00:00 EDT 2016
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
The Journal of clinical investigation
Zhu X,Messer JS,Wang Y,Lin F,Cham CM,Chang J,Billiar TR,Lotze MT,Boone DL,Chang EB
Mon Mar 02 00:00:00 EST 2015
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
Stem cell reports
Kido T,Koui Y,Suzuki K,Kobayashi A,Miura Y,Chern EY,Tanaka M,Miyajima A
Tue Oct 13 00:00:00 EDT 2015
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Cell
Karthaus WR,Iaquinta PJ,Drost J,Gracanin A,van Boxtel R,Wongvipat J,Dowling CM,Gao D,Begthel H,Sachs N,Vries RGJ,Cuppen E,Chen Y,Sawyers CL,Clevers HC
Thu Sep 25 00:00:00 EDT 2014
Organoid cultures derived from patients with advanced prostate cancer.
Cell
Gao D,Vela I,Sboner A,Iaquinta PJ,Karthaus WR,Gopalan A,Dowling C,Wanjala JN,Undvall EA,Arora VK,Wongvipat J,Kossai M,Ramazanoglu S,Barboza LP,Di W,Cao Z,Zhang QF,Sirota I,Ran L,MacDonald TY,Beltran H,Mosquera JM,Touijer KA,Scardino PT,Laudone VP,Curtis KR,Rathkopf DE,Morris MJ,Danila DC,Slovin SF,Solomon SB,Eastham JA,Chi P,Carver B,Rubin MA,Scher HI,Clevers H,Sawyers CL,Chen Y
Thu Sep 25 00:00:00 EDT 2014
Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.
Cell death & disease
Grabinger T,Luks L,Kostadinova F,Zimberlin C,Medema JP,Leist M,Brunner T
Thu May 15 00:00:00 EDT 2014
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Cancer cell
Cooks T,Pateras IS,Tarcic O,Solomon H,Schetter AJ,Wilder S,Lozano G,Pikarsky E,Forshew T,Rosenfeld N,Harpaz N,Itzkowitz S,Harris CC,Rotter V,Gorgoulis VG,Oren M
Mon May 13 00:00:00 EDT 2013
