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产品信息
RP-75738
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
Amino acids Val77-Leu233 containing an N-terminal His-tag
标签
His-tag
分类
Recombinant
类型
Protein
纯度
>95%, by SDS-PAGE under reducing conditions
偶联物
形式
Liquid
浓度
0.65 mg/mL
纯化类型
purified
保存液
20mM tris HCl, pH 8, with 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
RP-75738 contains purified recombinant human TNF alpha protein with an N-terminal hexahistidine tag.
RP-75738 may be used as a positive control in many immunological assays.
靶标信息
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
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生物信息学
蛋白别名: APC1 protein; Cachectin; DADB-70P7.1; TNF alpha; TNF superfamily; TNF α; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFα; Tumor necrosis factor; tumor necrosis factor ligand 1F; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
基因别名: DIF; TNF; TNF-alpha; TNFA; TNFSF2; TNLG1F
UniProt ID: (Human) P01375
Entrez Gene ID: (Human) 7124
