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产品信息
450-57-25UG
产品规格
种属
Mouse
已发表种属
Mouse
Expression System
E. coli
氨基酸序列
APNGTRHAEL GHGWDGLVAR SLARLPVAAQ PPQAAVRSGA GDYLLGLKRL RRLYCNVGIG FHLQVLPDGR IGGVHADTRD SLLELSPVQR GVVSIFGVAS RFFVAMSSRG KLFGVPFFTD ECKFKEILLP NNYNAYESYA YPGMFMALSK NGRTKKGNRV SPTMKVTHFL PRL
分子量
19 kDa
分类
Recombinant
类型
Protein
纯度
≥ 95% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 0.4-1.0 ng/ml.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
450-57-1MG will be provided as 2 x 500 µg (450-57-500UG).
Recombinant Murine FGF-4 is a 19.0 kDa protein consisting of 173 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FGF; FGF-4; Fibroblast growth factor; Fibroblast growth factor 4; HBGF-4; Heparin-binding growth factor 4; K-fibroblast growth factor
基因别名: Fgf-4; Fgf4; Fgfk; hst; hst-1; Hst1; Hstf-1; Kfgf; KS3
UniProt ID: (Mouse) P11403
Entrez Gene ID: (Mouse) 14175
