Gibco

Mouse G-CSF Recombinant Protein, PeproTech®

Mouse G-CSF Protein in Functional Assay (Functional)

图: 1 / 1

Mouse G-CSF Protein (250-05-10UG) in Functional

Bioassay analysis of Mouse G-CSF Recombinant Protein, PeproTech® (Product # 250-05-1MG).

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产品信息

250-05-10UG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

查看4篇已发表文章 4篇已发表文章

功能检测 (Functional)

Assay-dependent

体外检测 (IV)

查看95篇已发表文章 95篇已发表文章

其他PubMed (Misc)

查看19篇已发表文章 19篇已发表文章

产品规格

种属

Mouse

已发表种属

Human, Mouse, Non-human primate, Rat

Expression System

E. coli

氨基酸序列

MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA

分子量

19 kDa

分类

Recombinant

类型

Protein

纯度

≥ 98% by SDS-PAGE gel and HPLC analyses.

内毒素浓度

<1 EU/µg

活性

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

purified

内含物

no preservative

保存条件

-20°C

运输条件

Ambient

产品详细信息

Recombinant Murine G-CSF is a 19.0 kDa protein consisting of 179 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

靶标信息

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. G-CSF is highly conserved among species and has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors, neutrophilic granulocytes and certain carcinoma cell lines. Clinical use of G-CSF has been approved for several therapeutic applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet's syndrome and AIDS. Further, G-CSF has been shown to be a marker protein for different carcinomas such as bladder cancer and dysfunction of the protein has been linked to Kostmann Syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A culture platform to study quiescent hematopoietic stem cells following genome editing.

Cell reports methods

Shiroshita K,Kobayashi H,Watanuki S,Karigane D,Sorimachi Y,Fujita S,Tamaki S,Haraguchi M,Itokawa N,Aoyoama K,Koide S,Masamoto Y,Kobayashi K,Nakamura-Ishizu A,Kurokawa M,Iwama A,Okamoto S,Kataoka K,Takubo K

250-05 was used in Cell Culture to analyze HSC cell cycle quiescence by combining culture conditions that maintain quiescence with a CRISPR-Cas9 genome editing system optimized for HSCs.

Mon Dec 19 00:00:00 EST 2022

Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.

Science advances

Bonadonna M,Altamura S,Tybl E,Palais G,Qatato M,Polycarpou-Schwarz M,Schneider M,Kalk C,Rüdiger W,Ertl A,Anstee N,Bogeska R,Helm D,Milsom MD,Galy B

250-05 was used in Cell Culture to report that global disruption of both iron-regulatory protein 1 (IRP1) and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia.

Fri Oct 07 00:00:00 EDT 2022

The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.

Blood

Tu Z,Wang C,Davis AK,Hu M,Zhao C,Xin M,Lu QR,Zheng Y

Thu Jul 22 00:00:00 EDT 2021

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.

The Journal of experimental medicine

Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E

Mon Jul 05 00:00:00 EDT 2021

The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.

The Journal of experimental medicine

Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE

Mon Dec 06 00:00:00 EST 2021

Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity.

Glia

Vaes JEG,van Kammen CM,Trayford C,van der Toorn A,Ruhwedel T,Benders MJNL,Dijkhuizen RM,Möbius W,van Rijt SH,Nijboer CH

250-05 was used in Cell Culture to show that MSCs adapt their secretome after ex vivo exposure to dWMI milieu and identified several factors including IGF1, EGF, LIF, and IL11 that potently boost OL maturation.

Mon Mar 01 00:00:00 EST 2021

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

iScience

AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB

Fri Jun 25 00:00:00 EDT 2021

MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy.

Scientific reports

Tritz R,Hudson FZ,Harris V,Ghoshal P,Singla B,Lin H,Csanyi G,Stansfield BK

Tue Dec 21 00:00:00 EST 2021

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis.

Nature communications

Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG

Fri Jan 08 00:00:00 EST 2021

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.

Proceedings of the National Academy of Sciences of the United States of America

Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F

Tue Feb 11 00:00:00 EST 2020

CD62L^dim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer.

Frontiers in oncology

Wang Z,Yang C,Li L,Zhang Z,Pan J,Su K,Chen W,Li J,Qiu F,Huang J

250-05 was used in In vivo experiments to examine the critical time of the niche formation and detect a novel subset of CD62Ldim neutrophils.

Fri Nov 13 00:00:00 EST 2020

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG

Wed Jan 01 00:00:00 EST 2020

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kralova J,Drobek A,Prochazka J,Spoutil F,Fabisik M,Glatzova D,Borna S,Pokorna J,Skopcova T,Angelisova P,Gregor M,Kovarik P,Sedlacek R,Brdicka T

Sun Mar 15 00:00:00 EDT 2020

Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.

Journal of immunology (Baltimore, Md. : 1950)

Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D

Thu Oct 15 00:00:00 EDT 2020

Lentiviral gene therapy rescues p47^phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.

Gene therapy

Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G

Tue Sep 01 00:00:00 EDT 2020

G-CSF Inhibits Pulmonary Fibrosis by Promoting BMSC Homing to the Lungs via SDF-1/CXCR4 Chemotaxis.

Scientific reports

Zhao FY,Cheng TY,Yang L,Huang YH,Li C,Han JZ,Li XH,Fang LJ,Feng DD,Tang YT,Yue SJ,Tang SY,Luo ZQ,Liu W

Mon Jun 29 00:00:00 EDT 2020

MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.

Nature communications

Itskovich SS,Gurunathan A,Clark J,Burwinkel M,Wunderlich M,Berger MR,Kulkarni A,Chetal K,Venkatasubramanian M,Salomonis N,Kumar AR,Lee LH

Tue May 12 00:00:00 EDT 2020

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.

Cell

Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S

Thu Jul 11 00:00:00 EDT 2019

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Cell stem cell

Yamashita M,Passegué E

250-05 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.

Thu Sep 05 00:00:00 EDT 2019

G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche.

The Journal of clinical investigation

Li Z,Hardij J,Evers SS,Hutch CR,Choi SM,Shao Y,Learman BS,Lewis KT,Schill RL,Mori H,Bagchi DP,Romanelli SM,Kim KS,Bowers E,Griffin C,Seeley RJ,Singer K,Sandoval DA,Rosen CJ,MacDougald OA

Mon May 06 00:00:00 EDT 2019

Type I interferon induces CXCL13 to support ectopic germinal center formation.

The Journal of experimental medicine

Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA

Mon Mar 04 00:00:00 EST 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B

250-05 was used in Cell Culture to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.

Mon Feb 04 00:00:00 EST 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

250-05 was used in Cell Culture to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.

Mon Feb 04 00:00:00 EST 2019

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs.

The Journal of experimental medicine

Mastio J,Condamine T,Dominguez G,Kossenkov AV,Donthireddy L,Veglia F,Lin C,Wang F,Fu S,Zhou J,Viatour P,Lavilla-Alonso S,Polo AT,Tcyganov EN,Mulligan C,Nam B,Bennett J,Masters G,Guarino M,Kumar A,Nefedova Y,Vonderheide RH,Languino LR,Abrams SI,Gabrilovich DI

Mon Sep 02 00:00:00 EDT 2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.

Genes & development

Labi V,Peng S,Klironomos F,Munschauer M,Kastelic N,Chakraborty T,Schoeler K,Derudder E,Martella M,Mastrobuoni G,Hernandez-Miranda LR,Lahmann I,Kocks C,Birchmeier C,Kempa S,Quintanilla-Martinez de Fend L,Landthaler M,Rajewsky N,Rajewsky K

250-05 was used in Cell Culture to conclude that the interaction of miR-17∼92 with a single target is essential for life, and BIM regulation by miRNAs serves as a rheostat controlling cell survival in specific physiological contexts.

Sun Dec 01 00:00:00 EST 2019

Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.

Aging cell

Yue S,Zheng X,Zheng Y

Thu Aug 01 00:00:00 EDT 2019

Signaling and functional competency of neutrophils derived from bone-marrow cells expressing the ER-HOXB8 oncoprotein.

Journal of leukocyte biology

Saul S,Castelbou C,Fickentscher C,Demaurex N

Fri Nov 01 00:00:00 EDT 2019

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

Immunology and cell biology

McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC

Tue Jan 01 00:00:00 EST 2019

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

Nature communications

Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA

Fri Jan 04 00:00:00 EST 2019

Population snapshots predict early haematopoietic and erythroid hierarchies.

Nature

Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M

250-05 was used in Cell Culture to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.

Thu Mar 01 00:00:00 EST 2018

Population snapshots predict early haematopoietic and erythroid hierarchies.

Nature

Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M

250-05 was used in Cell Culture to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.

Thu Mar 01 00:00:00 EST 2018

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Cell

Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y

250-05 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.

Thu Sep 20 00:00:00 EDT 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Fri Jun 01 00:00:00 EDT 2018

Altered compensatory cytokine signaling underlies the discrepancy between and mice.

The Journal of experimental medicine

Durai V,Bagadia P,Briseño CG,Theisen DJ,Iwata A,Davidson JT,Gargaro M,Fremont DH,Murphy TL,Murphy KM

Mon May 07 00:00:00 EDT 2018

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

The Journal of experimental medicine

Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M

Mon Jul 02 00:00:00 EDT 2018

Intestinal host defense outcome is dictated by PGE₂ production during efferocytosis of infected cells.

Proceedings of the National Academy of Sciences of the United States of America

Dejani NN,Orlando AB,Niño VE,Penteado LA,Verdan FF,Bazzano JMR,Codo AC,Salina ACG,Saraiva AC,Avelar MR,Spolidorio LC,Serezani CH,Medeiros AI

Tue Sep 04 00:00:00 EDT 2018

Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection.

Journal of immunology (Baltimore, Md. : 1950)

Teitz-Tennenbaum S,Viglianti SP,Roussey JA,Levitz SM,Olszewski MA,Osterholzer JJ

Mon Oct 01 00:00:00 EDT 2018

Toxic adjuvants alter the function and phenotype of dendritic cells to initiate adaptive immune responses induced by oral Helicobacter pylori vaccines.

Helicobacter

Luo S,Liu W,Zeng Z,Ye F,Hu C,Xu N,Huang A,Xi T,Xing Y

Sat Dec 01 00:00:00 EST 2018

Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells.

Scientific reports

Rodrigues CFD,Serrano E,Patrício MI,Val MM,Albuquerque P,Fonseca J,Gomes CMF,Abrunhosa AJ,Paiva A,Carvalho L,Botelho MF,Almeida L,Carreira IM,Alpoim MC

Wed Aug 01 00:00:00 EDT 2018

Chlamydial Plasmid-Encoded Protein pGP3 Inhibits Development of Psoriasis-Like Lesions in Mice.

Medical science monitor : international medical journal of experimental and clinical research

Hou S,Xu R,Zhu C,Shan S,Han L,Wang H

250-05 was used in In vitro experiments to study the role of pGP3 in the development of lesions in mice with imiquimod-induced psoriasis.

Wed Jul 25 00:00:00 EDT 2018

Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.

Scientific reports

Nakamura J,Watanabe S,Kimura H,Kobayashi M,Karasawa T,Kamata R,Usui-Kawanishi F,Sadatomo A,Mizukami H,Nagi-Miura N,Ohno N,Kasahara T,Minota S,Takahashi M

Tue May 15 00:00:00 EDT 2018

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.

Immunity

Riffelmacher T,Clarke A,Richter FC,Stranks A,Pandey S,Danielli S,Hublitz P,Yu Z,Johnson E,Schwerd T,McCullagh J,Uhlig H,Jacobsen SEW,Simon AK

Tue Sep 19 00:00:00 EDT 2017

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

Cancer cell

Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W

Mon Jul 10 00:00:00 EDT 2017

BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.

Blood

Duggan JM,Buechler MB,Olson RM,Hohl TM,Hamerman JA

Thu Mar 16 00:00:00 EDT 2017

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

The Journal of experimental medicine

Karmaus PWF,Herrada AA,Guy C,Neale G,Dhungana Y,Long L,Vogel P,Avila J,Clish CB,Chi H

Mon Sep 04 00:00:00 EDT 2017

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.

Journal of immunology (Baltimore, Md. : 1950)

Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI

Mon May 15 00:00:00 EDT 2017

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.

Journal of immunology (Baltimore, Md. : 1950)

Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI

Mon May 15 00:00:00 EDT 2017

Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.

Scientific reports

MacNicol MC,Cragle CE,McDaniel FK,Hardy LL,Wang Y,Arumugam K,Rahmatallah Y,Glazko GV,Wilczynska A,Childs GV,Zhou D,MacNicol AM

Thu Sep 14 00:00:00 EDT 2017

High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia.

Blood

Hou Y,Feng Q,Xu M,Li GS,Liu XN,Sheng Z,Zhou H,Ma J,Wei Y,Sun YX,Yu YY,Qiu JH,Shao LL,Liu XG,Hou M,Peng J

Thu Mar 24 00:00:00 EDT 2016

Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.

Journal of immunology (Baltimore, Md. : 1950)

Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y

Sat Oct 15 00:00:00 EDT 2016

Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.

Journal of immunology (Baltimore, Md. : 1950)

Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P

Mon Aug 01 00:00:00 EDT 2016

Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.

Journal of immunology (Baltimore, Md. : 1950)

Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T

Sat Oct 15 00:00:00 EDT 2016

RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.

Blood cancer journal

Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M

Fri Jan 08 00:00:00 EST 2016

RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.

Blood cancer journal

Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M

Fri Jan 08 00:00:00 EST 2016

Impaired Mobilization of Vascular Reparative Bone Marrow Cells in Streptozotocin-Induced Diabetes but not in Leptin Receptor-Deficient db/db Mice.

Scientific reports

Vasam G,Joshi S,Jarajapu YP

Wed May 18 00:00:00 EDT 2016

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.

Nature

Coffelt SB,Kersten K,Doornebal CW,Weiden J,Vrijland K,Hau CS,Verstegen NJM,Ciampricotti M,Hawinkels LJAC,Jonkers J,de Visser KE

Thu Jun 18 00:00:00 EDT 2015

In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.

Blood

Messmann JJ,Reisser T,Leithäuser F,Lutz MB,Debatin KM,Strauss G

Thu Aug 27 00:00:00 EDT 2015

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.

Blood

Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS

Thu Feb 26 00:00:00 EST 2015

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.

Proceedings of the National Academy of Sciences of the United States of America

Casbon AJ,Reynaud D,Park C,Khuc E,Gan DD,Schepers K,Passegué E,Werb Z

Tue Feb 10 00:00:00 EST 2015

The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs.

Stem cells (Dayton, Ohio)

Land RH,Rayne AK,Vanderbeck AN,Barlowe TS,Manjunath S,Gross M,Eiger S,Klein PS,Cunningham NR,Huang J,Emerson SG,Punt JA

Thu Jan 01 00:00:00 EST 2015

Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice.

Journal of immunology (Baltimore, Md. : 1950)

Talabot-Ayer D,Martin P,Vesin C,Seemayer CA,Vigne S,Gabay C,Palmer G

Thu Jan 15 00:00:00 EST 2015

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Nature communications

Lawlor KE,Khan N,Mildenhall A,Gerlic M,Croker BA,D'Cruz AA,Hall C,Kaur Spall S,Anderton H,Masters SL,Rashidi M,Wicks IP,Alexander WS,Mitsuuchi Y,Benetatos CA,Condon SM,Wong WW,Silke J,Vaux DL,Vince JE

Wed Feb 18 00:00:00 EST 2015

Uric acid enhances the antitumor immunity of dendritic cell-based vaccine.

Scientific reports

Wang Y,Ma X,Su C,Peng B,Du J,Jia H,Luo M,Fang C,Wei Y

Tue Nov 10 00:00:00 EST 2015

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3.

Cell

Betschinger J,Nichols J,Dietmann S,Corrin PD,Paddison PJ,Smith A

Thu Apr 11 00:00:00 EDT 2013

miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.

Immunity

Sonda N,Simonato F,Peranzoni E,Calì B,Bortoluzzi S,Bisognin A,Wang E,Marincola FM,Naldini L,Gentner B,Trautwein C,Sackett SD,Zanovello P,Molon B,Bronte V

Thu Jun 27 00:00:00 EDT 2013

Runx3 deficiency results in myeloproliferative disorder in aged mice.

Blood

Wang CQ,Motoda L,Satake M,Ito Y,Taniuchi I,Tergaonkar V,Osato M

Thu Jul 25 00:00:00 EDT 2013

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.

The Journal of clinical investigation

Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW

Tue Jan 01 00:00:00 EST 2013

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis.

The Journal of clinical investigation

Waight JD,Netherby C,Hensen ML,Miller A,Hu Q,Liu S,Bogner PN,Farren MR,Lee KP,Liu K,Abrams SI

Tue Oct 01 00:00:00 EDT 2013

Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.

Blood cancer journal

Pannucci NL,Li D,Sahay S,Thomas EK,Chen R,Tala I,Hu T,Ciccarelli BT,Megjugorac NJ,Adams Iii HC,Rodriguez PL,Fitzpatrick ER,Lagunoff D,Williams DA,Whitehead IP

Fri Aug 16 00:00:00 EDT 2013

Mesenchymal stem cells are mobilized from the bone marrow during inflammation.

Frontiers in immunology

Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE

Wed Mar 06 00:00:00 EST 2013

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.

The Journal of cell biology

Liou GY,Döppler H,Necela B,Krishna M,Crawford HC,Raimondo M,Storz P

Mon Aug 05 00:00:00 EDT 2013

Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.

Oncogenesis

Ng KP,Hu Z,Ebrahem Q,Negrotto S,Lausen J,Saunthararajah Y

Mon Nov 04 00:00:00 EST 2013

Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.

Journal of immunology (Baltimore, Md. : 1950)

Liu Z,Petersen R,Devireddy L

Wed May 01 00:00:00 EDT 2013

CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis.

Journal of immunology (Baltimore, Md. : 1950)

Bian Z,Guo Y,Luo Y,Tremblay A,Zhang X,Dharma S,Mishra A,Liu Y

Tue Jan 01 00:00:00 EST 2013

IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation.

Journal of immunology (Baltimore, Md. : 1950)

Yan B,Wei JJ,Yuan Y,Sun R,Li D,Luo J,Liao SJ,Zhou YH,Shu Y,Wang Q,Zhang GM,Feng ZH

Sat Jun 01 00:00:00 EDT 2013

Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.

Journal of immunology (Baltimore, Md. : 1950)

Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y

Wed May 01 00:00:00 EDT 2013

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

PloS one

Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M

Fri Sep 27 00:00:00 EDT 2013

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

The Journal of biological chemistry

Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M

Fri Nov 15 00:00:00 EST 2013

IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.

Blood

de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA

Thu Feb 09 00:00:00 EST 2012

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.

Blood

Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ

Thu Jun 21 00:00:00 EDT 2012

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.

Blood

Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC

Thu Oct 11 00:00:00 EDT 2012

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

The Journal of experimental medicine

Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM

Mon Jun 04 00:00:00 EDT 2012

Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP

Mon Oct 01 00:00:00 EDT 2012

Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.

PloS one

Eftychi C,Karagianni N,Alexiou M,Apostolaki M,Kollias G

Tue Jul 31 00:00:00 EDT 2012

JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency.

Nature communications

van Oosten AL,Costa Y,Smith A,Silva JC

Tue May 08 00:00:00 EDT 2012

IL-36R ligands are potent regulators of dendritic and T cells.

Blood

Vigne S,Palmer G,Lamacchia C,Martin P,Talabot-Ayer D,Rodriguez E,Ronchi F,Sallusto F,Dinh H,Sims JE,Gabay C

Thu Nov 24 00:00:00 EST 2011

Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance.

Blood

Kreisel D,Sugimoto S,Zhu J,Nava R,Li W,Okazaki M,Yamamoto S,Ibrahim M,Huang HJ,Toth KA,Ritter JH,Krupnick AS,Miller MJ,Gelman AE

Thu Dec 01 00:00:00 EST 2011

In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.

Blood

Richie Ehrlich LI,Serwold T,Weissman IL

Thu Mar 03 00:00:00 EST 2011

Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.

Blood

Nanua S,Murakami M,Xia J,Grenda DS,Woloszynek J,Strand M,Link DC

Thu Mar 31 00:00:00 EDT 2011

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.

The Journal of clinical investigation

Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE

Sat Jan 01 00:00:00 EST 2011

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

The Journal of experimental medicine

Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA

Mon Jun 06 00:00:00 EDT 2011

Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.

The Journal of experimental medicine

Stock A,Booth S,Cerundolo V

Mon Apr 11 00:00:00 EDT 2011

Sortase-catalyzed transformations that improve the properties of cytokines.

Proceedings of the National Academy of Sciences of the United States of America

Popp MW,Dougan SK,Chuang TY,Spooner E,Ploegh HL

Tue Feb 22 00:00:00 EST 2011

Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.

Journal of immunology (Baltimore, Md. : 1950)

Maxwell MJ,Duan M,Armes JE,Anderson GP,Tarlinton DM,Hibbs ML

Wed Jun 15 00:00:00 EDT 2011

Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism.

PloS one

Waight JD,Hu Q,Miller A,Liu S,Abrams SI

Mon Mar 26 00:00:00 EDT 2012

R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.

The Journal of biological chemistry

Shang X,Cancelas JA,Li L,Guo F,Liu W,Johnson JF,Ficker A,Daria D,Geiger H,Ratner N,Zheng Y

Fri Jul 08 00:00:00 EDT 2011

Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development.

PloS one

Yamamoto M,Kato T,Hotta C,Nishiyama A,Kurotaki D,Yoshinari M,Takami M,Ichino M,Nakazawa M,Matsuyama T,Kamijo R,Kitagawa S,Ozato K,Tamura T

Thu Feb 02 00:00:00 EST 2012

Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.

Bone marrow research

Cai S,Wang H,Bailey B,Hartwell JR,Silver JM,Juliar BE,Sinn AL,Baluyut AR,Pollok KE

Thu Nov 10 00:00:00 EST 2011

Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.

PloS one

Cain DW,Snowden PB,Sempowski GD,Kelsoe G

Wed Oct 05 00:00:00 EDT 2011

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Nature

Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP

Thu Sep 16 00:00:00 EDT 2010

A reprogrammable mouse strain from gene-targeted embryonic stem cells.

Nature methods

Stadtfeld M,Maherali N,Borkent M,Hochedlinger K

Fri Jan 01 00:00:00 EST 2010

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Blood

Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS

Thu Aug 26 00:00:00 EDT 2010

Essential role for focal adhesion kinase in regulating stress hematopoiesis.

Blood

Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R

Thu Nov 18 00:00:00 EST 2010

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.

Blood

Vemula S,Shi J,Hanneman P,Wei L,Kapur R

Thu Mar 04 00:00:00 EST 2010

Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.

PloS one

Jiang D,Schwarz H

Mon Dec 13 00:00:00 EST 2010

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

Nature

Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG

Thu Jan 01 00:00:00 EST 2009

MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.

Cell

Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH

Thu Jul 23 00:00:00 EDT 2009

The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.

Blood

Kimura A,Rieger MA,Simone JM,Chen W,Wickre MC,Zhu BM,Hoppe PS,O'Shea JJ,Schroeder T,Hennighausen L

Thu Nov 19 00:00:00 EST 2009

Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.

Blood

Velu CS,Baktula AM,Grimes HL

Thu May 07 00:00:00 EDT 2009

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Blood

Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW