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产品信息
210-12P40H-10UG
产品规格
种属
Mouse
已发表种属
Mouse
Expression System
HEK293 cells
氨基酸序列
p40 subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
分子量
40 kDa
分类
Recombinant
类型
Protein
纯度
≥ 95% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12p70 in T cell-enriched PBMCs.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
210-12P40H-1MG will be provided as 2 x 500 µg (210-12P40H-500UG).
Recombinant Murine IL-12 p40 is a 40.0 kDa protein consisting of 313 amino acid residues and less than 5% of the IL-12 p80 dimer.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL-12 subunit p40; IL-12B; IL12 p40; IL12A; ILN; Interleukin; Interleukin 12; Interleukin-12 subunit beta; Interleukin12; RP23-388G23.1
基因别名: Il-12b; Il-12p40; Il12b; Il12p40; p40
UniProt ID: (Mouse) P43432
Entrez Gene ID: (Mouse) 16160
