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产品信息
PEP-0081
产品规格
种属反应
Mouse
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
This peptide corresponds to 14 amino acids of mouse RIP3.
PEP-0081 can be used as a blocking peptide with polyclonal antibody PA5-19956.
靶标信息
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mRIP3; receptor interacting protein 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3
基因别名: 2610528K09Rik; AW107945; Rip3; Ripk3
UniProt ID: (Mouse) Q9QZL0
Entrez Gene ID: (Mouse) 56532
