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产品信息
PEP-220
产品规格
种属反应
Mouse
氨基酸序列
SHPQKDDGDN PETI
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-220 is a 14 amino acid synthetic peptide corresponding to amino acid residues 359-372 from mouse S1P1. The sequence of this peptide is (amino to carboxy terminus): S (359) H P Q K D D G D N P E T I (372).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-1040. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD antigen CD363; CD363; CD363 antigen; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; Lysophospholipid receptor B1; S1P receptor 1; S1P receptor Edg-1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1
基因别名: AI849002; Edg1; Lpb1; S1p; S1p1; S1pr1
UniProt ID: (Mouse) O08530
Entrez Gene ID: (Mouse) 13609
