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b-tc3 细胞
| Organism Type | Mouse | The pancreatic beta-cell line has been established from insulinomas derived from transgenic mice carrying a hybrid insulin-promoted simian virus 40 tumor antigen gene. The cells produce both proinsulin I and II and efficiently process each into mature insulin, in a manner comparable to normal beta cells in isolated islets. Insulin secretion is inducible up to 30-fold by glucose, although with a lower threshold for maximal stimulation than that for normal beta cells. |
| Tissues | Pancreas | |
| Phenotype | Adherent | |
| Primary | no | |
| Application | Cell Culture / Growth Conditions,Transient Transfection |
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