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Human ADAMTS4 quantitates human ADAMTS4 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ADAMTS4.
This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : ADAMTS-2, ADAMTS-4, ADAMTS4, ADMP-1, KIAA0688, UNQ769/PRO1563
基因ID : (Human) 9507
基因符号 : ADAMTS4
蛋白别名 : A disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase, ADAM, ADAMs, Aggrecanase 1, metalloendopeptidases, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4, ADAM metallopeptidase with thrombospondin type 1 motif, ADAM-TS 4, ADAM-TS4, ADMP-1, Aggrecanase-1
UniProt ID (Human) O75173