SM(PEG)24(聚乙二醇化,长链 SMCC 交联剂)
SM(PEG)24(聚乙二醇化,长链 SMCC 交联剂)
Thermo Scientific™

SM(PEG)24(聚乙二醇化,长链 SMCC 交联剂)

Thermo Scientific Pierce SM(PEG)n is a series of amine-to-sulfhydryl crosslinkers that differ in length from 17.6 to 95.2 angstroms as了解更多信息
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货号 22114
价格(CNY)/ Each
价格10,447.00
飞享价8,357.19仅限网单直购,无需促销代码
(ends 31-Dec-2024)
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数量:
100 mg
价格(CNY)/ Each
飞享价8,357.19仅限网单直购,无需促销代码
(ends 31-Dec-2024)
添加至购物车
SM(PEG)24(聚乙二醇化,长链 SMCC 交联剂)
货号22114
价格(CNY)/ Each
飞享价8,357.19仅限网单直购,无需促销代码
(ends 31-Dec-2024)
-
添加至购物车
Thermo Scientific Pierce SM(PEG)n is a series of amine-to-sulfhydryl crosslinkers that differ in length from 17.6 to 95.2 angstroms as a result of polyethylene glycol spacer arms containing n equals 2 to 24 ethylene glycol units.

Features of SM(PEG)24:

Reactive groups: NHS ester and maleimide
Reactive toward: amino and sulfhydryl groups
• Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
• Polyethylene glycol spacer arms help maintain conjugate solubility
• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Ideal for performing controlled, two-step protein conjugations (see Sulfo-SMCC)

SM(PEG)n NHS- and maleimide-activated PEG compounds for crosslinking between primary amines (NH2) and sulfhydryl (SH) groups in proteins and other molecules. A complete set of compounds are offered, each having the same heterobifunctional structure (NHS-PEGn-Maleimide) but differing in the number of discrete ethylene glycol units ( n = 2, 4, 6, 8, 12 or 24). The N-hydroxysuccinimide ester (NHS) group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. The maleimide group reacts with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bonds.

Alternative Names for SM(PEG)n:
• NHS-dPEG-Mal
• Mal-PEG NHS ester
• NHS-PEO-Maleimide
• Succinimidyl-dPEG-maleimide
• Succinimide-Maleimide PEG

Why use crosslinkers with polyethylene glycol (PEG) spacer arms?
PEG-containing reagents have been used to modify proteins to provide specific advantages. Protein PEGylation can improve the stability of the modified protein, protect it from proteolytic digestion, increase its half life in a biological application, mask it from causing an immunogenic response, decrease its antigenicity or potential toxicity, improve its solubility, diminish the potential for aggregation, and minimize interference for both in vitro and in vivo applications. Polyethylene glycol has these effects because it is nontoxic, nonimmunogenic, hydrophilic, water soluble and highly flexible.

Advantages of discrete-length polyethylene glycol compounds:
These reagents are specially synthesized, resulting in homogeneous compounds of defined molecular weight, characterized by discrete chain lengths, providing a greater ability to optimize and characterize surface protein modifications. Typical preparations of PEG compounds are a heterogeneous mixtures composed of a distribution of chain lengths with a specified average molecular weight or approximate number of PEG subunits.

Related Products
SM(PEG)6 (PEGylated, long-chain SMCC crosslinker)
SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)
SM(PEG)12 (PEGylated, long-chain SMCC crosslinker)
仅供科研使用。不可用于诊断程序。
规格
化学反应性胺-巯基
可裂解
描述SM(PEG)24
分子量1394.55
聚乙二醇化
间隔臂长95.2 Å
细胞渗透性
运输条件环境
产品线Pierce™
标记方法化学标记
交联剂类型异型双功能团试剂
反应一部分马来酰亚胺、NHS 酯
间隔子长 (>30 Å̊)
形式实心
数量100 mg
溶解度
产品规格标准
水溶性
产品类型交联剂
Unit SizeEach
内容与储存
接收后在 -20°C 下干燥储存。