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NeoBiotechnologies
NKX2.2 Recombinant Rabbit Monoclonal Antibody (NX2, 1422R)
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Product Details
4821-RBM2-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
NX2, 1422R
Immunogen
Recombinant human full-length NKX2.2 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; Nkx2.2
Gene Aliases: NKX2-2; NKX2.2; NKX2B
UniProt ID: (Human) O95096
Entrez Gene ID: (Human) 4821
type B pancreatic cell development
pancreatic A cell fate commitment
type B pancreatic cell fate commitment
pancreatic PP cell fate commitment
transcription, DNA-templated
smoothened signaling pathway
brain development
response to glucose
oligodendrocyte development
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell fate specification
optic nerve development
endocrine pancreas development
response to progesterone
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
neuron fate specification
astrocyte differentiation
positive regulation of oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
ventral spinal cord interneuron fate determination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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