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Invitrogen
NRXN1 Recombinant Rabbit Monoclonal Antibody (22H29L23)
Application
FIGURE: 1 / 2
NRXN1 Antibody (703650) in ICC/IF
Knockdown of NRXN1 was achieved by transfecting U-87 MG cells with specific siRNA (Silencer® select Product # s17948, s17947). Immunofluorescence analysis was performed on U-87VMG cells (untransfected, panel a-d), transfected with NRXN1 specific siRNA (panel i-l) or non-specific scrambled siRNA (panels e-h). Cells were fixed, permeabilized, and labelled with Anti-NRXN1 Recombinant Rabbit Monoclonal Antibody (Product # 703650, 1:100 dilution), followed by Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 c... View More
Product Details
703650
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
22H29L23
Immunogen
Peptides corresponding to human NRXN1 [aa296-aa313, aa394-aa406]
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809243
Product Specific Information
This antibody is predicted to react with Monkey, Cat, Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp313P2036; FLJ35941; Neurexin 1alpha; neurexin I; Neurexin I-alpha; Neurexin I-beta; Neurexin-1; Neurexin-1-alpha; Neurexin-1-beta
Gene Aliases: Hs.22998; KIAA0578; NRXN1; PTHSL2; SCZD17
UniProt ID: (Human) Q9ULB1
Entrez Gene ID: (Human) 9378
neuron cell-cell adhesion
chemical synaptic transmission
neurotransmitter secretion
axon guidance
synapse assembly
learning
adult behavior
social behavior
vocal learning
neuromuscular process controlling balance
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
regulation of insulin secretion involved in cellular response to glucose stimulus
vocalization behavior
positive regulation of synapse maturation
postsynaptic membrane assembly
gephyrin clustering involved in postsynaptic density assembly
neuroligin clustering involved in postsynaptic membrane assembly
postsynaptic density protein 95 clustering
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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