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THRA/THRB Antibody (MA5-45922) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using differentiated SH-SY5Y cells. Samples were incubated with Thyroid Hormone Receptor monoclonal antibody (Product # MA5-45922) at 1:250, followed by AlexaFluor 488. Counterstain used was phalloidin (Alexa 647, red), beta tubulin (Anti-beta III Tubulin Ab, Alexa 555, magenta) Hoechst (blue). (A) Phalloidin (B) Anti-beta III Tubulin Ab. (C) Thyroid Hormone R... View More
产品信息
MA5-45922
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
H43
抗原
Synthetic peptide from the full length Human Thyroid hormone receptor protein
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine
内含物
no preservative
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A 1:500 dilution of MA5-45922 was sufficient for detection of Pan-Thyroid hormone receptor in 10 µg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects 70 kDa.
靶标信息
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA-1; c-erbA-2; C-erbA-alpha; c-erbA-alpha2; c-erbA-beta; c-erbAalpha; c-erbAalpha2; EAR-7; ERBA-related 7; Nuclear receptor subfamily 1 group A member 1; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; THR; thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); thyroid normone nuclear receptor alpha variant 1; TR; TR alpha 1; TR alpha 2; TR beta; TRbeta2Delta; triiodothyronine receptor; V-erbA-related protein 7
基因别名: 6430529J03Rik; AR7; AW259572; c-ERBA-1; C-ERBA-2; C-erba-alpha; C-ERBA-BETA; c-erbAbeta; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; ERBA2; GRTH; NR1A1; NR1A2; PRTH; RATT3REC; Rvr; T3R[a]; T3R[b]; T3Ralpha; T3Rbeta; T3rec; THR1; THRA; THRA1; THRA2; THRB; THRB1; THRB2; TRbeta
UniProt ID: (Human) P10827, (Human) P10828, (Mouse) P63058, (Rat) P63059, (Mouse) P37242
Entrez Gene ID: (Human) 7067, (Human) 7068, (Mouse) 21833, (Rat) 81812, (Mouse) 21834, (Rat) 24831
