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Application
FIGURE: 1 / 3
Npr2 Antibody (MA5-50136) in ICC/IF
Immunocytochemistry analysis of HeLa with Npr2 monoclonal antibody (Product # MA5-50136) at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 501-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Product Details
MA5-50136
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
19C7
Immunogen
A synthesized peptide derived from Human NPR2
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3092518
Target Information
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANP-B; ANPR-B; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); NPR-B
Gene Aliases: AMDM; ANPb; ANPRB; ECDM; GUC2B; GUCY2B; NPR2; NPRB; NPRBi; SNSK
UniProt ID: (Human) P20594
Entrez Gene ID: (Human) 4882
ossification
cGMP biosynthetic process
protein phosphorylation
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of oocyte maturation
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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