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Application
FIGURE: 1 / 2
Ankyrin B Antibody (MA5-55908) in IHC (P)
Immunohistochemistry analysis of Ankyrin B in paraffin-embedded cerebral cortex tissue. Sample was incubated with Ankyrin B monoclonal antibody (Product # MA5-55908) at a dilution of 5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at roo... View More
Product Details
MA5-55908
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
K52014_1E12
Immunogen
Recombinant human ANK2 (immunogen range is 11-310).
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Specific Information
Sequence of this protein is as follows: DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL TPLHCAARSG
Target Information
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-2; ankyrin B; ankyrin, brain; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin
Gene Aliases: ANK-2; ANK2; ANKB; brank-2; LQT4
UniProt ID: (Human) Q01484
Entrez Gene ID: (Human) 287
regulation of heart rate
atrial septum development
cellular calcium ion homeostasis
ER to Golgi vesicle-mediated transport
cytoskeleton organization
positive regulation of gene expression
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
paranodal junction assembly
regulation of protein stability
T-tubule organization
protein localization to organelle
protein localization to cell surface
cellular protein localization
protein localization to M-band
protein localization to T-tubule
positive regulation of potassium ion transport
protein stabilization
regulation of release of sequestered calcium ion into cytosol
response to methylmercury
regulation of calcium ion transport
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
sarcoplasmic reticulum calcium ion transport
protein localization to endoplasmic reticulum
protein localization to plasma membrane
protein targeting to plasma membrane
regulation of cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
atrial cardiac muscle cell action potential
SA node cell action potential
membrane depolarization during SA node cell action potential
atrial cardiac muscle cell to AV node cell communication
SA node cell to atrial cardiac muscle cell communication
regulation of heart rate by cardiac conduction
regulation of SA node cell action potential
regulation of atrial cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transporter activity
regulation of calcium ion transmembrane transporter activity
positive regulation of calcium ion transmembrane transporter activity
positive regulation of cation channel activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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