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Product Details
PA5-96816
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 149-448 of human INPP5K (NP_0576162)
Conjugate
Unconjugated
Form
Liquid
Concentration
1.51 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808618
Product Specific Information
Immunogen sequence: HLPPHISNNY QRLEHFDRIL EMQNCEGRDI PNILDHDLII WFGDMNFRIE DFGLHFVRES IKNRCYGGLW EKDQLSIAKK HDPLLREFQE GRLLFPPTYK FDRNSNDYDT SEKKRKPAWT DRILWRLKRQ PCAGPDTPIP PASHFSLSLR GYSSHMTYGI SDHKPVSGTF DLELKPLVSA PLIVLMPEDL WTVENDMMVS YSSTSDFPSS PWDWIGLYKV GLRDVNDYVS YAWVGDSKVS CSDNLNQVYI DISNIPTTED EFLLCYYSNS LRSVVGISRP FQIPPGSLRE DPLGEAQPQI; Positive Samples: Mouse brain, Rat brain; Cellular Location: Endoplasmic reticulum
Target Information
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C62; Inositol polyphosphate 5-phosphatase K; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PI-5-phosphatase related; putative phosphoinositide 5-phosphatase type II; putative phosphoinositide 5-phosphatase type II; C62; putative PI-5-phosphatase; skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase
Gene Aliases: C62; INPP5K; PPS; SKIP
UniProt ID: (Human) Q9BT40, (Mouse) Q8C5L6
Entrez Gene ID: (Human) 51763, (Rat) 287533, (Mouse) 19062
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
vasopressin receptor activity
protein binding
inositol bisphosphate phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol trisphosphate phosphatase activity
phosphatidylinositol phosphate 5-phosphatase activity
lipid phosphatase activity
inositol trisphosphate phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
molecular_function
hydrolase activity
phosphatase
in utero embryonic development
negative regulation of protein phosphorylation
regulation of glycogen biosynthetic process
negative regulation of protein kinase activity
phosphatidylinositol biosynthetic process
G-protein coupled receptor signaling pathway
negative regulation of peptidyl-threonine phosphorylation
negative regulation of glucose transport
dephosphorylation
actin cytoskeleton organization
cellular response to insulin stimulus
cellular response to hormone stimulus
negative regulation of peptidyl-serine phosphorylation
negative regulation of dephosphorylation
positive regulation of urine volume
glucose homeostasis
negative regulation of MAP kinase activity
negative regulation by host of viral transcription
negative regulation of glycogen biosynthetic process
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
inositol phosphate dephosphorylation
phosphatidylinositol dephosphorylation
negative regulation of stress fiber assembly
negative regulation of protein kinase B signaling
negative regulation of calcium ion transport
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
protein targeting to plasma membrane
negative regulation of protein targeting to membrane
ruffle assembly
negative regulation of glycogen (starch) synthase activity
positive regulation of renal water transport
biological_process
response to insulin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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