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Separate hydrophobic cations using the solvent-compatible cation-exchange Thermo Scientific™ OmniPac™ PCX-100 Column. This polymer-based cation-exchange column is solvent compatible and stable over the entire pH range of 1-14. Solvents may be used to affect selectivity, solubilize otherwise insoluble samples, and to remove contaminants to prolong column lifetime. The OmniPac PCX-100 column is particularly well suited for the analysis of hydrophobic cationic analytes including amines, anilines, antidepressants, drugs, and metabolites (such as methotrexate and folic acid).