SMPB (succinimidyl 4-(p-maleimidophenyl)butyrate)

Thermo Scientific Pierce SMPB is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length aromatic spacer arm (11.6 angstroms).

Features of SMPB:

• Reactive groups: NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• Extended chain analog of MBS
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)
• Conjugates formed with SMPB are more stable in serum than SPDP conjugates

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)