MT(PEG)4 Methyl-PEG-Thiol Compound

Thermo Scientific Pierce MT(PEG)4, or methyl-PEG4-thiol, is a methyl- and sulfhydryl-terminated compound that contains a 4-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles.

Features of MT(PEG)4:

• Metal-binding—terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding
• Methyl—terminal methyl group is unreactive, the primary function of this compound being to coat quantum dot and other surfaces to reduce nonspecific binding in assays
• Polyethylene glycol—PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods
• Spacer arm—four-unit PEG spacer makes compound nearly 16 angstroms long

MT(PEG)4 is monodentate thiol-terminated and methyl pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with polyethylene glycol spacers such as this one significantly reduces nonspecific protein binding.

The use of MT(PEG)4 with CT(PEG)12 in surface modification can form a hydrophilic 'lawn' of methyl ether-terminated PEGs with periodic exposed carboxylic acid-containing PEGs. The exposed carboxylic acid groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

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