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MKP3 Antibody (PA5-22162) in WB
Western Blot using MKP3 Polyclonal Antibody (Product # PA5-22162). Sample (50 µg of whole cell lysate). Lane A: mouse liver. 10% SDS PAGE. MKP3 Polyclonal Antibody (Product # PA5-22162) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
PA5-22162
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 82 and 370 of DUSP6 (Uniprot ID#Q16828)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11157647
产品详细信息
Recommended positive controls: HepG2, mouse liver, rat liver.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (88%), Xenopus laevis (93%), Pig (99%), Chicken (97%), Rhesus Monkey (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUSP6-ALT; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; serine/threonine specific protein phosphatase
基因别名: 1300019I03Rik; DUSP6; HH19; MKP-3; MKP3; PYST1
UniProt ID: (Human) Q16828, (Rat) Q64346, (Mouse) Q9DBB1
Entrez Gene ID: (Human) 1848, (Rat) 116663, (Mouse) 67603
MAPK cascade
activation of MAPK activity
inactivation of MAPK activity
dorsal/ventral pattern formation
response to organic cyclic compound
cell differentiation
peptidyl-tyrosine dephosphorylation
regulation of fibroblast growth factor receptor signaling pathway
response to drug
regulation of endodermal cell fate specification
positive regulation of apoptotic process
response to nitrosative stress
regulation of heart growth
negative regulation of ERK1 and ERK2 cascade
response to growth factor
negative regulation of protein phosphorylation
protein dephosphorylation
response to organic substance
positive regulation of cell death
dephosphorylation
