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产品信息
PA1-4619
产品规格
种属反应
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser133 of rat CREB1 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2230004
产品详细信息
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, rat, sheep, Xenopus and zebrafish based on 100% sequence homology.
This antibody is specific for the ~45 kDa CREB phosphorylated at Ser133 in Western blots of rat brain lysates. Immunolabeling can be blocked by lambda-phosphatase treatment.
靶标信息
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cAMP response element binding protein 1; cAMP-responsive element-binding protein 1; CREB-1; Cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; Y protein
基因别名: 2310001E10Rik; 3526402H21Rik; AV083133; Creb; Creb-1; Creb1
UniProt ID: (Mouse) Q01147, (Rat) P15337
Entrez Gene ID: (Mouse) 12912, (Rat) 81646
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
enzyme binding
histone acetyltransferase binding
cAMP response element binding
sequence-specific DNA binding
transcription regulatory region DNA binding
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
transforming growth factor beta receptor signaling pathway
axonogenesis
lactation
memory
circadian rhythm
regulation of cell size
response to organic substance
negative regulation of transcription by competitive promoter binding
pituitary gland development
cell differentiation
mammary gland development
positive regulation of transforming growth factor beta3 production
secretory granule organization
response to glucagon
positive regulation of multicellular organism growth
response to drug
regulation of circadian rhythm
regulation of apoptotic process
positive regulation of fat cell differentiation
positive regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
positive regulation of lipid biosynthetic process
rhythmic process
protein stabilization
lung epithelium development
lung saccule development
Type I pneumocyte differentiation
cellular response to zinc ion
cellular response to growth factor stimulus
