Invitrogen

Caveolin 3 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

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9 篇参考文献
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产品信息

PA1-066

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-3 µg/mL
查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:200
-

免疫细胞化学 (ICC/IF)

1-2 µg/mL
查看6篇已发表文章 6篇已发表文章

免疫沉淀 (IP)

5 µg
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues M(1) M T E E H T D L E A R I I K D I H C(19) C of mouse CAV3
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2072446

产品详细信息

PA1-066 detects Caveolin 3 from rat and mouse tissues. This antibody does not detect caveolin-1 or -2.

PA1-066 has been successfully used in Western blot, IF, immunocytochemistry and immunoprecipitation procedures. By Western blot, this antibody detects an ~21 kDa protein representing Caveolin 3 from rat heart homogenate.

The PA1-066 immunogen is a synthetic peptide corresponding to residues M(1) M T E E H T D L E A R I I K D I H C(19) C of mouse CAV3. This sequence is ~85% conserved in human Caveolin 3. PA1-066 immunizing peptide (Cat. # PEP-081) is available for use in neutralization and control experiments.

靶标信息

Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CAV; Caveolin-3; M-caveolin; MGC126100; MGC126101; MGC126129

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基因别名: AI385751; Cav-3; CAV3; LGMD1C; LQT9; M-cav; VIP-21; VIP21

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UniProt ID: (Human) P56539, (Rat) P51638, (Mouse) P51637

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Entrez Gene ID: (Human) 859, (Rat) 29161, (Mouse) 12391

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功能
calcium channel regulator activity protein binding protein C-terminus binding sodium channel regulator activity potassium channel inhibitor activity protein complex binding protein complex scaffold alpha-tubulin binding ion channel binding nitric-oxide synthase binding connexin binding enzyme binding scaffold/adaptor protein
参与通路
plasma membrane repair regulation of heart rate negative regulation of protein kinase activity triglyceride metabolic process endocytosis muscle contraction plasma membrane organization actin filament organization positive regulation of cytosolic calcium ion concentration muscle organ development myoblast fusion regulation of heart contraction protein localization positive regulation of cell proliferation negative regulation of cardiac muscle hypertrophy positive regulation of myotube differentiation regulation of skeletal muscle contraction cell growth regulation of transforming growth factor beta receptor signaling pathway cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization membrane raft organization T-tubule organization detection of muscle stretch regulation of signal transduction by receptor internalization regulation of membrane potential glucose homeostasis cholesterol homeostasis negative regulation of MAP kinase activity negative regulation of MAPK cascade negative regulation of cell size muscle cell cellular homeostasis negative regulation of nitric-oxide synthase activity regulation of nerve growth factor receptor activity nucleus localization regulation of protein kinase B signaling negative regulation of calcium ion transport cardiac muscle cell development regulation of cardiac muscle contraction negative regulation of sarcomere organization regulation of ventricular cardiac muscle cell membrane repolarization heart trabecula formation regulation of ventricular cardiac muscle cell membrane depolarization regulation of branching involved in mammary gland duct morphogenesis negative regulation of cell growth involved in cardiac muscle cell development caveola assembly protein localization to plasma membrane ventricular cardiac muscle cell action potential establishment of protein localization to plasma membrane regulation of calcium ion import regulation of p38MAPK cascade regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of protein localization to cell surface positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of sodium ion transmembrane transporter activity positive regulation of caveolin-mediated endocytosis myotube differentiation regulation of calcium ion transport
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